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Tag: Outcomes Research

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REDISCOVER-ICU: Utilizing Data to Study Drug Repurposing Beyond COVID-19

The COVID-19 pandemic exposed significant gaps in the healthcare system, such as healthcare inequities and the need for more treatment options for intensive care unit patients with serious illnesses. Looking beyond COVID-19 to sepsis and other critical care illnesses, the Society of Critical Care Medicine and Critical Path Institute’s CURE Drug Repurposing Collaboratory are collaborating on the new study Repurposing Drugs in Intensive Care Units Through Real-World Data Analysis (REDISCOVER-ICU).

Big Data Leads to the Discovery Data Science Campaign

The Discovery Data Science Campaign was launched in 2022 to improve the care of critically ill patients by leveraging the use of large-scale data (big data) for research. The campaign’s goal is to apply findings from data analysis in a clinical environment through standardized data models and shared resources, starting with the 2023 Datathon.

SCCM Pod-51 SCCM Members Launch Major Sepsis Study

Derek Angus, MD, MPH, discusses a new, multicenter research consortium, called Protocolized Care for Early Septic Shock (ProCESS).

SCCM Pod-94 Increased Mortality of Ventilated Patients with Endotracheal Pseudomonas Aeruginosa

Jeanine Wiener-Kronish, MD, discusses an article published in the September 2008 issue of Critical Care Medicine, titled "Increased Mortality of Ventilated Patients with Endotracheal Pseudomonas Aeruginosa Without Clinical Signs of Infection."

SCCM Pod-98 Congress Preview: Angus Discusses Critical Care Research

Derek C. Angus, MD, MPH, FCCM, the recipient of the American College of Critical Care Medicine's (ACCM) Distinguished Investigator Award, discusses the state of critical care research as well as his unique background.

SCCM Pod-153 Council Member Shares SCCM Experiences, Sepsis Research

Craig Coopersmith, MD, FCCM, shares how early involvement within the Society, his receiving the Vision Grant, and his participation in Specialty Sections helped shape his career, while stressing the importance of mentorship.

SCCM Pod-161 Clifford Deutschman on Sepsis Research, SCCM Involvement

SCCM president-elect Clifford S. Deutschman, MD, FCCM, professor of anesthesiology and critical care at the University of Pennsylvania School of Medicine in Philadelphia, shares how his involvement within SCCM helped shape aspects of his career.

SCCM Pod-172 PCCM: A Closer Look at the Critical Pertussis Study

Carol E. Nicholson, MD, MS, FAAP, is the Project Scientist for the Collaborative Pediatric Critical Care Research Network (CPCCRN) and Program Director for Pediatric Care and Rehabilitation Research (PCCR). Nicholson discusses the results of the CPCCRNs critical pertussis study, which sought to characterize the condition, its change over time and the level of support required for pediatric patients.

SCCM Pod-184 PCCM: Health-Related Outcomes in Children

Margaret Parker, MD, FCCM, associate podcast editor, speaks with Nana Coleman, MD, EdM, about her editorial published in the July Pediatric Critical Care Medicine, “Health-Related Outcomes in Children After Critical Illness.”

SCCM Pod-193 CCM: Research Consent Discrepancies Between Patients and Surrogates

Michael S. Weinstein, MD, FACS, FCCP, speaks with Marc Moss, MD, lead author of an article published in the September Critical Care Medicine, “Surrogate and Patient Discrepancy Regarding Consent for Critical Care Research.”

SCCM Pod-199 PCCM: Stem Cell Transplant Outcomes

Margaret Parker, MD, FCCM, speaks with Ranjit S. Chima, MD, lead author of an article that demonstrated a 63% survival to ICU discharge and a 45% long-term survival in hematopoietic stem cell transplant patients needing PICU care.

SCCM Pod-239 Hypertension and Health Outcomes in the PICU

Margaret Parker, MD, MCCM, speaks with Brett J. Ehrmann, MD, MS, about the article, “Hypertension and Health Outcomes in the PICU,” published in Pediatric Critical Care Medicine.

SCCM Pod-241 Stem Cell Therapies in Critical Illness

Michael Weinstein, MD, FACS, FCCP, speaks with Michael Matthay, MD, Professor of Medicine and Anesthesia at the University of California at San Francisco and a Senior Associate at the Cardiovascular Research Institute. Dr. Matthay discusses “Stem Cell Therapies in Critical Illness,” along with some thoughts on the treatment of ARDS and clinical trials in general.

SCCM Pod-264 44th Critical Care Congress: RESTORE Study

Margaret Parker, MD, MCCM, speaks with Martha Curley, RN, PhD, about "Protocolized Sedation vs Usual Care in Pediatric Patients Mechanically Ventilated for Acute Respiratory Failure: A Randomized Clinical Trial," published January 2015 in The Journal of the American Medical Association.

SCCM Pod-268 Results from the EPIC II Study

Ludwig Lin, MD, speaks with Jean-Louis Vincent, MD, PhD, FCCM, about the article, “The Impact of Hospital and ICU Organizational Factors on Outcome in Critically Ill Patients: Results from the Extended Prevalence of Infection in Intensive Care Study,” published in Critical Care Medicine.

SCCM Pod-275 44th Critical Care Congress: Is Repair After AKI Linked to Long-Term Outcomes?

Todd Fraser, MD, speaks with John Kellum, MD, MCCM, Professor of Critical Care Medicine at the University of Pittsburgh in Pittsburgh, Pennsylvania. In this interview, Dr. Kellum discusses the concept of renal repair after acute kidney injury and its link to significant long-term outcomes in critically ill patients.

SCCM Pod-282 A Qualitative Study Exploring Moral Distress in the ICU Team

Michael S. Weinstein, MD, FACS, FCCM, speaks with Janice L. Zimmerman, MD, and Courtenay R. Bruce, JD, MA, about the article, “A Qualitative Study Exploring Moral Distress in the ICU Team: The Importance of Unit Functionality and Intrateam Dynamics*,” published in Critical Care Medicine.

SCCM Pod-285 Trial of the Route of Early Nutritional Support in Critically Ill Adults

Todd Fraser, MD, speaks with Monty Mythen, MD, about the article, “Trial of the Route of Early Nutritional Support in Critically Ill Adults,” published in The New England Journal of Medicine in 2014.

SCCM Pod-302 Feeding Critically Ill Children and Outcomes

Margaret Parker, MD, MCCM, speaks with Ann-Marie Brown, ACNP, PhD, RN, FCCM, Assistant Professor of Nursing at the University of Akron and Advanced Practice Nurse in the Pediatric Intensive Care Unit at Akron Children’s Hospital in Akron, Ohio.

SCCM Pod-316 The SPLIT Randomized Clinical Trial

Todd Fraser, MD, speaks with Paul Young, FCICM, about the article, “Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial,” published in The Journal of the American Medical Association.

SCCM Pod-334 Vasopressors: Future Research

Margaret Parker, MD, MCCM, speaks with Lakhmir S. Chawla, MD, about future research related to the Congress session “Bench-Pressing in the ICU: Which Vasopressor Agent Should I Choose for My Patient?” which he presented at the 45th Critical Care Congress in Orlando, Florida

SCCM Pod-353 Are Biomarkers Ready for Prime Time?

Kyle Enfield, MD, speaks with John A. Kellum, MD, MCCM, about his talk presented at the 46th Critical Care Congress in Honolulu, Hawaii entitled, “Are Biomarkers Ready for Prime Time?”

SCCM Pod-354 The Septic Shock 3.0 Definition and Trials

Ranjit Deshpande, MD, speaks with James A. Russell, MD, about the article, “The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience,” published in the June 2017 issue of Critical Care Medicine.

SCCM Pod-377 Procalcitonin Guidance in Patients with Sepsis

Ludwig H. Lin, MD, and Philipp Schuetz, MD, discuss procalcitonin and how it impacts treatment of sepsis. This podcast originated from the article "Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis" (Iankova I, et al. Crit Care Med. 2018;46:691-698).

SCCM Pod-390 Telehealth and Patient Outcomes

Ranjit Deshpande, MD, and Donna Lee Armaignac, PhD, APRN, CCNS, CCRN, discuss maximizing positive patient care outcomes through telemedicine.

SCCM Pod-420 Nebulized Bacteriophages for Prophylaxis of Experimental MRSA VAP

Alternative strategies are needed to combat and prevent antibiotic-resistant bacterial infections. Host Ashish K. Khanna, MD, FCCP, FCCM, talks about this issue with David R. Cameron, PhD.

SCCM Pod-445 The Association of Workload and Outcomes in the Pediatric Cardiac ICU

Host Elizabeth Mack, MD, MS, FCCM, is joined by Michael Fundora, MD, FAAP, to discuss if the hypothesized frontline clinician workload, measured by bed occupancy and staffing, is associated with poor outcomes and unnecessary testing.

Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination

From Critical Care Explorations  While the overall safety profile of the BNT162b2 coronavirus disease 2019 vaccine remains excellent for the general population, rare serious events have been reported. In this case report, the authors describe a case of multisystem inflammation and organ dysfunction of unknown mechanism beginning shortly after administration of the first dose of BNT162b2 coronavirus disease 2019 vaccine in a previously healthy recipient.

Thrombocytopenia After Coronavirus Disease 2019 Vaccination: Remember to Put the Blame on Others Too

From Critical Care Medicine. This Editorial accompanies the article by Iba et. al titled "Recognizing vaccine-induced immune thrombotic thrombocytopenia".

Using Nonheparin Anticoagulant to Treat a Near-Fatal Case With Multiple Venous Thrombotic Lesions During ChAdOx1 nCoV-19 Vaccination-Related Vaccine-Induced Immune Thrombotic Thrombocytopenia

From Critical Care Medicine. The authors describe the successful recovery from multiple and life-threatening venous thrombosis after ChAdOx1 nCoV-19 vaccination.

Help Shape the Future of Sepsis Research on the National Level

The National Institute of General Medical Sciences (NIGMS) is changing its priorities to invest in sepsis research in a more targeted and strategic way. In an important opportunity to help shape the future of sepsis research, NIGMS has issued a request for information related to its new priorities. The request for information is found here and is due by November 15, 2019.

Concise Critical Appraisal: Effect of Sodium Bicarbonate Infusion on Patient Outcomes

Jaber et al (Lancet. 2018;392:31-40) set out to evaluate the effect of sodium bicarbonate infusion on critically ill patient outcomes.

Concise Critical Appraisal: The Effect of Ramelteon Administration on the Duration of ICU Stay

Nishikimi et al (Crit Care Med. 2018;46:1099-1105) set out to identify the effects of ramelteon, a melatonin agonist, on ICU length of stay for critically ill patients.

Concise Critical Appraisal: Fluid Administration and Diabetic Ketoacidosis

Kuppermann et al (N Engl J Med. 2018;378:2275-2287) sought to prospectively determine the role that fluid makeup and rate have on the development of neurologic injury in children with DKA.

Concise Critical Appraisal: Cerebral Oxygen Metabolism and RBC Transfusion in Infants

Neunhoeffer et al (Pediatr Crit Care Med. 2018;19:318-327) sought to use noninvasive means to determine the changes in cerebral oxygen metabolism in infants younger than 6 months who have undergone major surgery.