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A global COVID-19 registry that tracks ICU and hospital care patterns in near real time
Viral Infection and Respiratory Illness Universal Study (VIRUS) is a prospective, cross-sectional, observational study and registry of all eligible adult and pediatric patients who are admitted to a hospital. There is no intervention or patient interaction. Only de-identified data are used for analysis. ClinicalTrials.gov Identifier: NCT04323787
VIRUS COVID-19 Registry Dashboard
Please check whether your site is already enrolled as a VIRUS participating site before enrolling. Then complete the intake form and download the frequently asked questions.
A waiver of informed consent for data collection is being requested for this study from participating sites. No patients will be contacted, but clinicians participating in the study will be surveyed for feedback and satisfaction. For any questions, contact Vishakha Kumar.
ICUs participating in the VIRUS Registry may also be among the 20 sites participating in the STOP-VIRUS collaborative. For more information about this network of ICUs, its leaders and participants, and the learning material being developed, click here.
Press releases and news articles highlighting VIRUS activities.
Coronavirus Disease 2019 in Pediatric Oncology Patients: A Matched-Cohort Analysis of the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry Balakumar N, Catueno S, Nadiger M, et al. Coronavirus disease 2019 in pediatric oncology patients: a matched-cohort analysis of the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry. J Pediatr Hematol Oncol. 2023 Apr 1;45(3):e309-e314. doi: 10.1097/MPH.0000000000002588. Program Type: VIRUS DISCOVERY
The Impact of Steroids on Outcomes of Children Admitted to the Hospital With Non-MISC COVID-19: An Analysis from the SCCM Discovery Network Virus Registry Nadiger M, Harthan A, McGarvey JS, et al. The impact of steroids on outcomes of children admitted to the hospital with Non-MISC COVID-19: an analysis from the SCCM Discovery Network Virus Registry. Pediatric Critical Care Medicine Conference: 11th Congress of the World Federation of Pediatric Intensive and Critical Care Societies (WFPICCS). 2022;23(11 Supplement 1). Program Type: VIRUS DISCOVERY
Association of Early Steroid Administration With Outcomes of Children Hospitalized for COVID-19 Without Multisystem Inflammatory Syndrome in Children Tripathi S, Nadiger M, McGarvey JS, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Association of early steroid administration with outcomes of children hospitalized for COVID-19 without multisystem inflammatory syndrome in children. JAMA Pediatr. 2022 Oct 3. Online ahead of print. doi:10.1001/jamapediatrics.2022.3611. Program Type: VIRUS DISCOVERY
Pre-Hospital Aspirin Use and Patient Outcomes in COVID-19: Results From the International Viral Infection and Respiratory Illness Universal Study (VIRUS) Lal A, Garces JP, Bansal V, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Pre-hospital aspirin use and patient outcomes in COVID-19: results from the International Viral Infection and Respiratory Illness Universal Study (VIRUS). Arch Bronconeumol. 2022 Sep 8;S0300-2896(22)00510-5. Online ahead of print. doi:10.1016/j.arbres.2022.07.017. Program Type: VIRUS DISCOVERY
Gastrointestinal Manifestations in Hospitalized Children With Acute SARS-CoV-2 Infection and Multisystem Inflammatory Condition: An Analysis of the VIRUS COVID-19 Registry Sayed IA, Bhalala U, Strom L, et al; VIRUS Investigators. Pediatr Infect Dis J. 2022 Sep 1;41(9):751-758. doi:10.1097/INF.0000000000003589. Program Type: VIRUS DISCOVERY
View All Discovery Articles
Mayo Clinic Rochester, Minnesota, USA
Boston University Boston, Massachusettes, USA
Mayo Clinic Foundation Rochester, Minnesota, USA
Discovery, the Critical Care Research Network Society of Critical Care Medicine
Submission process: Ancillary study proposals may be submitted for a subset of de-identified data for research purposes by investigators of participating sites in the VIRUS study. Proposals are submitted via an online submission portal. Submitted proposals are reviewed by the Discovery VIRUS Publication Review Workgroup for approval and feedback. Datasets may be made available to outside groups (nonparticipating sites and investigators) after initial publication of the data by study principal investigators within 12 months of study conclusion. A Data Use Agreement must be in place for this type of request. Review Process: The Discovery VIRUS Publication Review Workgroup will assign two to three reviewers per proposal. The timeline for approval is up to 30 days.
The proposal submission portal is now open. Access the submission portal.