SCCM is updating its SCCM Connect Community. Access to SCCM Connect may be limited until April 23.

Discovery VIRUS COVID-19 Registry

A global COVID-19 registry that tracks ICU and hospital care patterns in near real time

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Viral Infection and Respiratory Illness Universal Study (VIRUS) is a prospective, cross-sectional, observational study and registry of all eligible adult and pediatric patients who are admitted to a hospital. There is no intervention or patient interaction. Only de-identified data are used for analysis.

ClinicalTrials.gov Identifier: NCT04323787

VIRUS COVID-19 Registry Dashboard

 

SCCM




 
                  

VIRUS COVID-19 Registry Enrollment

Please check whether your site is already enrolled as a VIRUS participating site before enrolling. Then complete the intake form and download the frequently asked questions.

Check the VIRUS Participation List
Complete the Intake Form to Participate
Download VIRUS FAQs
 

Inclusion Criteria

  • COVID-19 PCR (or other SARS-CoV-2) test positive within 21 days
  • COVID-19 PCR pending
  • COVID-19 high clinical suspicion

Primary Aims

  • Create a real-time COVID-19 registry of current ICU and hospital care patterns to allow evaluation of safety and observational effectiveness of COVID-19 practices
  • Determine practice variations across hospitals

Hypotheses

The registry will be essential for near-real-time observational comparative effectiveness studies to determine effective treatment strategies and/or provide meaningful hypotheses for clinical trials.


Institutional Review Board: Waiver of Consent

A waiver of informed consent for data collection is being requested for this study from participating sites. No patients will be contacted, but clinicians participating in the study will be surveyed for feedback and satisfaction. For any questions, contact Vishakha Kumar.
 

Join the SCCM Connect Discovery Group

Approved sites with IRB approval can join the SCCM Connect Discovery Group. Access includes a discussion board and the ability to connect with other Discovery participants.

This is the best way to get regular updates about VIRUS!

Request to join the Discovery SCCM Connect Group
 

STOP-VIRUS ICU Learning Collaborative

ICUs participating in the VIRUS Registry may also be among the 20 sites participating in the STOP-VIRUS collaborative. For more information about this network of ICUs, its leaders and participants, and the learning material being developed, click here.


Recent Publications

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic
Cervantes-Arslanian AM, Venkata C, Anand P, et al. Crit Care Explor. 2022 Apr 25;4(4):e0686. doi: 10.1097/CCE.0000000000000686.
Program Type: VIRUS

Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database
Turek JR, Bansal V, Tekin A, et al. JMIR Res Protoc. 2022 Mar 15;11(3):e27921. doi: 10.2196/27921.
Program Type: VIRUS

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry
Tekin A, Qamar S, Singh R, et al; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. World J Crit Care Med. 2022 Mar 9;11(2):102-111. doi: 10.5492/wjccm.v11.i2.102.
Program Type: VIRUS

Cutaneous manifestations of hospitalized COVID-19 patients in the VIRUS COVID-19 registry
Deo N, Tekin A, Bansal V, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Int J Dermatol. 2022 May;61(5):623-625. doi: 10.1111/ijd.16134.
Program Type: VIRUS

Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19
Johnson SW, Garcia MA, Sisson EKQ, et al. Crit Care Explor. 2022 Feb 18;10(2):e0638. doi: 10.1097/CCE.0000000000000638.
Program Type: VIRUS

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VIRUS Investigators 

Discovery, the Critical Care Research Network, is leading the efforts for this global COVID-19 registry. 
Rahul Kashyap, MBA, MD
VIRUS Principal Investigator
Rahul Kashyap, MBA, MD

Mayo Clinic
Rochester, Minnesota, USA

Allan J. Walkey, MD, MSc
VIRUS Co-Principal Investigator
Allan J. Walkey, MD, MSc

Boston University
Boston, Massachusettes, USA

Juan Pablo Domecq Garces, MD
VIRUS Co-Principal Investigator
Juan Pablo Domecq Garces, MD

Mayo Clinic Foundation
Rochester, Minnesota, USA

Vishakha Kumar, MD, MBA
VIRUS Co-Principal Investigator
Vishakha Kumar, MD, MBA

Discovery, the Critical Care Research Network
Society of Critical Care Medicine


VIRUS Ancillary Studies

Ancillary Proposal Review Process

Submission process: Ancillary study proposals may be submitted for a subset of de-identified data for research purposes by investigators of participating sites in the VIRUS study. Proposals are submitted via an online submission portal. Submitted proposals are reviewed by the Discovery VIRUS Publication Review Workgroup for approval and feedback.

Datasets may be made available to outside groups (nonparticipating sites and investigators) after initial publication of the data by study principal investigators within 12 months of study conclusion. A Data Use Agreement must be in place for this type of request.

Review Process: The Discovery VIRUS Publication Review Workgroup will assign two to three reviewers per proposal. The timeline for approval is up to 30 days.

The proposal submission portal is now open. Access the submission portal.

 

Information for Investigators

  1. Any conflict of interest with the ancillary study proposal must be disclosed by reviewers and investigators.
  2. Ancillary study proposals are kept blinded from the VIRUS core investigator group.
  3. SCCM, including the VIRUS core investigators group, has first right of publication on the dataset for research hypotheses outlined for the VIRUS Study.
  4. Study participants can serve on the writing group with the VIRUS core investigators team if their ancillary study ideas overlap or align with the VIRUS overall project aims.
  5. National and international collaboration on ancillary proposal submission is encouraged.
  6. Ancillary proposal approval and data sharing depends on data quality and completion of the investigator’s own site data for the VIRUS study.

Ancillary Study Approval Process

Manuscript Approval Process

Ancillary Study Approval Process

Feedback on proposals will be shared with investigators. The Discovery VIRUS Publication Review Workgroup makes rapid review of proposals a priority. Once approved, investigators receive access to the de-identified subset of data from the VIRUS dataset.