Publications

Discovery, the Critical Care Research Network Publications

A Path to Real-World Evidence in Critical Care Using Open-Source Data Harmonization Tools
Heavner SF, Anderson W, Kashyap R, et al. A path to real-world evidence in critical care using open-source data harmonization tools. Crit Care Explor. 2023 Apr 3;5(4):e0893. doi: 10.1097/CCE.0000000000000893.
Program Type: CURE-ID DISCOVERY

Coronavirus Disease 2019 in Pediatric Oncology Patients: A Matched-Cohort Analysis of the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry
Balakumar N, Catueno S, Nadiger M, et al. Coronavirus disease 2019 in pediatric oncology patients: a matched-cohort analysis of the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry. J Pediatr Hematol Oncol. 2023 Apr 1;45(3):e309-e314. doi: 10.1097/MPH.0000000000002588.
Program Type: VIRUS DISCOVERY

Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic
Anesi GL, Andrews A, Bai H, et al; for the Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study Group. Perceived hospital stress, severe acute respiratory syndrome coronavirus 2 activity, and care process temporal variance during the COVID-19 pandemic. Crit Care Med. 2023 Feb 15. doi: 10.1097/CCM.0000000000005802. Online ahead of print.
Program Type: SARI-PREP DISCOVERY

Leveraging the SCCM Discovery VIRUS COVID-19 Registry to Evaluate Drug Repurposing Research Dataset
Heavner S, Howard K, Pauley M, et al. Leveraging the SCCM Discovery VIRUS COVID-19 Registry to evaluate drug repurposing research dataset. Abstract 1126. Presented at Society of Critical Care Medicine Annual Congress, January 23, 2023. Crit Care Med. 2023 Jan;51(1):561. doi: 0.1097/01.ccm.0000910240.21305.8d.
Program Type: CURE-ID DISCOVERY

The Impact of Steroids on Outcomes of Children Admitted to the Hospital With Non-MISC COVID-19: An Analysis from the SCCM Discovery Network Virus Registry
Nadiger M, Harthan A, McGarvey JS, et al. The impact of steroids on outcomes of children admitted to the hospital with Non-MISC COVID-19: an analysis from the SCCM Discovery Network Virus Registry. Pediatric Critical Care Medicine Conference: 11th Congress of the World Federation of Pediatric Intensive and Critical Care Societies (WFPICCS). 2022;23(11 Supplement 1).
Program Type: VIRUS DISCOVERY

Association of Early Steroid Administration With Outcomes of Children Hospitalized for COVID-19 Without Multisystem Inflammatory Syndrome in Children
Tripathi S, Nadiger M, McGarvey JS, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Association of early steroid administration with outcomes of children hospitalized for COVID-19 without multisystem inflammatory syndrome in children. JAMA Pediatr. 2022 Oct 3. Online ahead of print. doi:10.1001/jamapediatrics.2022.3611.
Program Type: VIRUS DISCOVERY

Severe Acute Respiratory Infection—Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections
Postelnicu R, Srivastava A, Bhatraju PK, et al; Society of Critical Care Medicine Discovery Network Investigators. Severe Acute Respiratory Infection—Preparedness: protocol for a multicenter prospective cohort study of viral respiratory infections. Crit Care Explor: 2022 Oct 20;4(10):e0773. doi: 10.1097/CCE.0000000000000773
Program Type: SARI-PREP DISCOVERY

Pre-Hospital Aspirin Use and Patient Outcomes in COVID-19: Results From the International Viral Infection and Respiratory Illness Universal Study (VIRUS)
Lal A, Garces JP, Bansal V, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Pre-hospital aspirin use and patient outcomes in COVID-19: results from the International Viral Infection and Respiratory Illness Universal Study (VIRUS). Arch Bronconeumol. 2022 Sep 8;S0300-2896(22)00510-5. Online ahead of print. doi:10.1016/j.arbres.2022.07.017.
Program Type: VIRUS DISCOVERY

Gastrointestinal Manifestations in Hospitalized Children With Acute SARS-CoV-2 Infection and Multisystem Inflammatory Condition: An Analysis of the VIRUS COVID-19 Registry
Sayed IA, Bhalala U, Strom L, et al; VIRUS Investigators. Pediatr Infect Dis J. 2022 Sep 1;41(9):751-758. doi:10.1097/INF.0000000000003589.
Program Type: VIRUS DISCOVERY

Variation in Use of High-Flow Nasal Cannula and Noninvasive Ventilation Among Patients With COVID-19
Garcia MA, Johnson SW, Sisson EK, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Respir Care. 2022 Aug;67(8):929-938. doi:10.4187/respcare.09672.
Program Type: VIRUS DISCOVERY

Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19
Gupta N, Settle L, Brown BR, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Crit Care Med. 2022 Jul 27. 10.1097/CCM.0000000000005627. Online ahead of print.
Program Type: VIRUS DISCOVERY

Early Combination Therapy With Immunoglobulin and Steroids Is Associated With Shorter ICU Length of Stay in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With COVID19: A Retrospective Cohort Analysis From 28 U.S Hospitals
Harthan AA, Nadiger M, McGarvey JS, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Pharmacotherapy. 2022 Jul;42(7):529-539. doi:10.1002/phar.2709.
Program Type: VIRUS DISCOVERY

Admission Code Status and End-of-Life Care for Hospitalized Patients With COVID-19
Kiker WA, Cheng S, Pollack LR, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group.  J Pain Symptom Manage. 2022 Jun 25;S0885-3924(22)00788-6. doi:10.1016/j.jpainsymman.2022.06.014.
Program Type: VIRUS DISCOVERY

The Association of Latitude and Altitude With COVID-19 Symptoms: A VIRUS: COVID-19 Registry Analysis
Tekin A, Qamar S, Bansal V, et al. Open Respir Med J. 2022;16.
Program Type: VIRUS DISCOVERY

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic
Cervantes-Arslanian AM, Venkata C, Anand P, et al. Crit Care Explor. 2022 Apr 25;4(4):e0686. doi: 10.1097/CCE.0000000000000686.
Program Type: VIRUS

Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database
Turek JR, Bansal V, Tekin A, et al. JMIR Res Protoc. 2022 Mar 15;11(3):e27921. doi: 10.2196/27921.
Program Type: VIRUS

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry
Tekin A, Qamar S, Singh R, et al; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. World J Crit Care Med. 2022 Mar 9;11(2):102-111. doi: 10.5492/wjccm.v11.i2.102.
Program Type: VIRUS

Association of Latitude and Altitude With Adverse Outcomes in Patients With COVID-19: The VIRUS Registry
Tekin A, Qamar S, Singh R, et al; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. World J Crit Care Med. 2022 Mar 9;11(2):102-111. doi:10.5492/wjccm.v11.i2.102.
Program Type: VIRUS DISCOVERY

Cutaneous manifestations of hospitalized COVID-19 patients in the VIRUS COVID-19 registry
Deo N, Tekin A, Bansal V, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Int J Dermatol. 2022 May;61(5):623-625. doi: 10.1111/ijd.16134.
Program Type: VIRUS

Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19
Johnson SW, Garcia MA, Sisson EKQ, et al. Crit Care Explor. 2022 Feb 18;10(2):e0638. doi: 10.1097/CCE.0000000000000638.
Program Type: VIRUS

Association of hypothyroidism with outcomes in hospitalized adults with COVID‐19: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry in Clinical Endocrinology
Bogojevic M, Bansal V, Pattan V, Singh R, Tekin A, Sharma M, La Nou AT, LeMahieu AM, Hanson AC, Schulte PJ, Deo N, Qamar S, Zec S, Valencia Morales DJ, Perkins N, Kaufman M, Denson JL, Melamed R, Banner-Goodspeed VM, Christie AB, Tarabichi Y, Heavner S, Kumar VK, Walkey AJ, Gajic O, Bhagra S, Kashyap R, Lal A, Domecq JP; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Association of hypothyroidism with outcomes in hospitalized adults with COVID-19: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry. Clin Endocrinol (Oxf). 2022 Feb 18. doi: 10.1111/cen.14699.
Program Type: VIRUS

Palliative care consultation and end-of-life outcomes in hospitalized COVID-19 patients
Cheruku SR, Barina A, Kershaw CD, Goff K, Reisch J, Hynan LS, Ahmed F, Armaignac DL, Patel L, Belden KA, Kaufman M, Christie AB, Deo N, Bansal V, Boman K, Kumar VK, Walkey A, Kashyap R, Gajic O, Fox AA; Society of Critical Care Medicine Discovery Viral Infection, Respiratory Illness Universal Study VIRUS: COVID-19 Registry Investigator Group. Palliative care consultation and end-of-life outcomes in hospitalized COVID-19 patients. Resuscitation. 2021 Dec 14;170:230-237.
Program Type: DISCOVERY

Palliative Care Consultation and End-of-Life Outcomes in Hospitalized COVID-19 Patients
Cheruku SR, Barina A, Kershaw CD, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Resuscitation. 2022 Jan;170:230-237. doi:10.1016/j.resuscitation.2021.12.011.
Program Type: VIRUS DISCOVERY

Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19
Denson JL, Gillet AS, Zu Y, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. JAMA Netw Open. 2021 Dec 1;4(12):e2140568. doi:10.1001/jamanetworkopen.2021.40568.
Program Type: VIRUS DISCOVERY

Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19
Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19. JAMA Netw Open. 2021 Dec 1;4(12):e2140568
Program Type: DISCOVERY

Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group
Garcia MA, Johnson SW, Bosch NA, Sisson EK, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Deo N, Domecq JP, Lal A, Christie AB, Banner-Goodspeed VM, Sanghavi D, Vadgaonkar G, Gajic O, Kashyap R, Walkey AJ. Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group. Crit Care Explor. 2021 Nov 2;3(11):e0566.
Program Type: VIRUS DISCOVERY

Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry
Amer M, Kamel AM, Bawazeer M, Maghrabi K, Butt A, Dahhan T, Kseibi E, Khurshid SM, Abujazar M, Alghunaim R, Rabee M, Abualkhair M, Al-Janoubi A, AlFirm AT, Gajic O, Walkey AJ, Mosier JM, Zabolotskikh IB, Gavidia OY, Teruel SY, Bernstein MA, Boman K, Kumar VK, Bansal V, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry. Eur J Med Res. 2021 Oct 2;26(1):117.
Program Type: VIRUS DISCOVERY

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome
Sulaiman I, Chung M, Angel L, et al. Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome. Nat Microbiol. 2021 Oct;6(10):1245-1258.
Program Type: SARI-PREP DISCOVERY

Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry
Tripathi S, Sayed IA, Dapul H, McGarvey JS, Bandy JA, Boman K, Kumar VK, Bansal V, Retford L, Cheruku S, Kaufman M, Heavner SF, Danesh VC, St Hill CA, Khanna AK, Bhalala U, Kashyap R, Gajic O, Walkey AJ, Gist KM. Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry. Crit Care Explor. 2021 Aug 20;3(8):e0514.
Program Type: VIRUS DISCOVERY

Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry
Bhalala US, Gist KM, Tripathi S, Boman K, Kumar VK, Retford L, Chiotos K, Blatz AM, Dapul H, Verma S, Sayed IA, Gharpure VP, Bjornstad E, Tofil N, Irby K, Sanders RC Jr, Heneghan JA, Thomas M, Gupta MK, Oulds FE, Arteaga GM, Levy ER, Gupta N, Kaufman M, Abdelaty A, Shlomovich M, Medar SS, Iqbal O'Meara AM, Kuehne J, Menon S, Khandhar PB, Miller AS, Barry SM, Danesh VC, Khanna AK, Zammit K, Stulce C, McGonagill PW, Bercow A, Amzuta IG, Gupta S, Almazyad MA, Pierre L, Sendi P, Ishaque S, Anderson HL 3rd, Nawathe P, Akhter M, Lyons PG, Chen C, Walkey AJ, Bihorac A, Wada Bello I, Ben Ari J, Kovacevic T, Bansal V, Brinton JT, Zimmerman JJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry. Crit Care Med. 2021 Aug 16.
Program Type: VIRUS DISCOVERY

Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events
Anesi G, Sevransky J, Cobb J, Evans L. Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events. 2021 Jun.
Program Type: SARI-PREP DISCOVERY

The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children with COVID-19
Tripathi S, Christison AL, Levy E, McGravery J, Tekin A, Bolliger D, Kumar VK, Bansal V, Chiotos K, Gist KM, Dapul HR, Bhalala US, Gharpure VP, Heneghan JA, Gupta N, Bjornstad EC, Montgomery VL, Walkey A, Kashyap R, Arteaga GM. The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children with COVID-19. Hosp Pediatr. 2021 Jun 24:e2021006087. doi: 10.1542/hpeds.2021-006087. 
Program Type: VIRUS DISCOVERY

Variation in Early Management Practices in Moderate-to-Severe Acute Respiratory Distress Syndrome in the United States
Qadir N, Bartz RR, Cooter ML, Hough CL, Lanspa MJ, Banner-Goodspeed VM, Chen JT, Giovanni S, Gomaa D, Sjoding MW, Hajizadeh N, Komisarow J, Duggal A, Khanna AK, Kashyap R, Khan A, Chang SY, Tonna JE, Anderson HL 3rd, Liebler JM, Mosier JM, Morris PE, Genthon A, Louh IK, Tidswell M, Stephens RS, Esper AM, Dries DJ, Martinez AA, Schreyer KE, Bender W, Tiwari A, Guru PK, Hanna S, Gong MN, Park PK; SAGE Investigators, on behalf of SCCM Discovery. Variation in Early Management Practices in Moderate-to-Severe Acute Respiratory Distress Syndrome in the United States. Chest. 2021 Jun 2:S0012-3692(21)01078-3. 
Program Type: CERTAIN DISCOVERY

Checklist for Early Recognition and Treatment of Acute Illness and Injury: An Exploratory Multicenter International Quality-Improvement Study in the ICUs With Variable Resources
Vukoja M, Dong Y, Adhikari NKJ, Schultz MJ, Arabi YM, Martin-Loeches I, Hache M, Gavrilovic S, Kashyap R, Gajic O; Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN) Investigators of the SCCM Discovery Network and Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN) Investigators. Checklist for Early Recognition and Treatment of Acute Illness and Injury: An Exploratory Multicenter International Quality-Improvement Study in the ICUs With Variable Resources. Crit Care Med. 2021 Jun 1;49(6):e598-e612. 
Program Type: CERTAIN DISCOVERY

Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry
Tripathi S, Gist KM, Bjornstad EC, Kashyap R, Boman K, Chiotos K, Gharpure VP, Dapul H, Sayed IA, Kuehne J, Heneghan JA, Gupta M, Khandhar PB, Menon S, Gupta N, Kumar VK, Retford L, Zimmerman J, Bhalala US; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry. Pediatr Crit Care Med. 2021 May 10. 
Program Type: VIRUS DISCOVERY

Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study
Bhatraju PK, Morrell ED, Zelnick L, Sathe NA, Chai XY, Sakr SS, Sahi SK, Sader A, Lum DM, Liu T, Koetje N, Garay A, Barnes E, Lawson J, Cromer G, Bray MK, Pipavath S, Kestenbaum BR, Liles WC, Fink SL, West TE, Evans L, Mikacenic C, Wurfel MM. Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study. Crit Care. 2021 Apr 19;25(1):148.
Program Type: SARI-PREP DISCOVERY

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial
Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall A, Hinson JS, Hooper MH, Kelen GD, Khan A, Levine MA, Lewis RJ, Lindsell CJ, Marlin JS, McGlothlin A, Moore BL, Nugent KL, Nwosu S, Polito CC, Rice TW, Ricketts EP, Rudolph CC, Sanfilippo F, Viele K, Martin GS, Wright DW; VICTAS Investigators. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. JAMA. 2021 Feb 23;325(8):742-750.
Program Type: VICTAS DISCOVERY

Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry
Domecq JP, Lal A, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Harhay MO, Garcia MA, Kaufman M, Danesh V, Cheruku S, Banner-Goodspeed VM, Anderson HL 3rd, Milligan PS, Denson JL, St Hill CA, Dodd KW, Martin GS, Gajic O, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2021 Mar 1;49(3):437-448.
Program Type: VIRUS DISCOVERY

Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry
Walkey AJ, Sheldrick RC, Kashyap R, Kumar VK, Boman K, Bolesta S, Zampieri FG, Bansal V, Harhay MO, Gajic O. Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2020 Nov;48(11):e1038-e1044.  
Program Type: VIRUS DISCOVERY

Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock
Roberts RJ, Miano TA, Hammond DA, Patel GP, Chen JT, Phillips KM, Lopez N, Kashani K, Qadir N, Cairns CB, Mathews K, Park P, Khan A, Gilmore JF, Brown ART, Tsuei B, Handzel M, Chang AL, Duggal A, Lanspa M, Herbert JT, Martinez A, Tonna J, Ammar MA, Nazer LH, Heavner M, Pender E, Chambers L, Kenes MT, Kaufman D, Downey A, Brown B, Chaykosky D, Wolff A, Smith M, Nault K, Gong MN, Sevransky JE, Lat I; Observation of VariatiOn in fLUids adMinistEred in shock-CHaracterizAtion of vaSoprEssor Requirements in Shock (VOLUME-CHASERS) Study Group and SCCM Discovery Network. Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock. Crit Care Med. 2020 Oct;48(10):1445-1453.  
Program Type: VOLUME-CHASERS DISCOVERY

Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study
Smischney NJ, Khanna AK, Brauer E, Morrow LE, Ofoma UR, Kaufman DA, Sen A, Venkata C, Morris P, Bansal V. Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study. J Intensive Care Med. 2020 Oct 1:885066620962445. 
Program Type: HEMAIR DISCOVERY

Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study
Smischney NJ, Kashyap R, Khanna AK, Brauer E, Morrow LE, Seisa MO, Schroeder DR, Diedrich DA, Montgomery A, Franco PM, Ofoma UR, Kaufman DA, Sen A, Callahan C, Venkata C, Demiralp G, Tedja R, Lee S, Geube M, Kumar SI, Morris P, Bansal V, Surani S; SCCM Discovery (Critical Care Research Network of Critical Care Medicine) HEMAIR Investigators Consortium. Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study. PLoS One. 2020 Aug 31;15(8):e0233852. 
Program Type: HEMAIR DISCOVERY

Effectiveness of a Daily Rounding Checklist on Processes of Care and Outcomes in Diverse Pediatric Intensive Care Units Across the World
Kashyap R, Murthy S, Arteaga GM, Dong Y, Cooper L, Kovacevic T, Basavaraja C, Ren H, Qiao L, Zhang G, Sridharan K, Jin P, Wang T, Tuibeqa I, Kang A, Ravi MD, Ongun E, Gajic O, Tripathi S; SCCM Discovery CERTAINp Collaborative Investigators. Effectiveness of a Daily Rounding Checklist on Processes of Care and Outcomes in Diverse Pediatric Intensive Care Units Across the World. J Trop Pediatr. 2020 Aug 27:fmaa058. 
Program Type: CERTAIN DISCOVERY

The Viral Infection and Respiratory Illness Universal Study (VIRUS): An International Registry of Coronavirus 2019-Related Critical Illness
Walkey AJ, Kumar VK, Harhay MO, Bolesta S, Bansal V, Gajic O, Kashyap R. The Viral Infection and Respiratory Illness Universal Study (VIRUS): An International Registry of Coronavirus 2019-Related Critical Illness. Crit Care Explor. 2020 Apr 29;2(4):e0113.  
Program Type: VIRUS DISCOVERY

Association Between Hospital Mortality and Inspiratory Airway Pressures in Mechanically Ventilated Patients Without Acute Respiratory Distress Syndrome: A Prospective Cohort Study
Sahetya SK, Mallow C, Sevransky JE, et al; Society of Critical Care Medicine Discovery Network Critical Illness Outcomes Study Investigators. Association between hospital mortality and inspiratory airway pressures in mechanically ventilated patients without acute respiratory distress syndrome: a prospective cohort study. Crit Care. 2019 Nov 21;23(1):367. doi: 10.1186/s13054-019-2635-y.
Program Type: USCIITG-CIOS DISCOVERY

Current practices and safety of medication use during rapid sequence intubation:  A multicenter study evaluating practices across the United States
Groth C, Acquisto NM, Khadem T.  Current practices and safety of medication use during rapid sequence intubation:  A multicenter study evaluating practices across the United States.  J Crit Care  2018;45:65-70. Epub 2018 Jan 30.
Program Type: DISCOVERY

Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients
Seethala RR, Hou PC, Aisiku IP, Frendl G, Park PK, Mikkelsen ME, Chang SY, Gajic O, Sevransky J. Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients. Ann Intensive Care. 2017 Dec;7(1):11.
Program Type: USCIITG-LIPS-1 DISCOVERY

Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome
Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE. Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May;45(5):798-805.
Program Type: USCITTG-LIPS-B DISCOVERY

Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States Hospitals
Kadri SS, Miller AC, Hohmann S, Bonne S, Nielsen C, Wells C, Gruver C, Quraishi SA, Sun J, Cai R, Morris PE, Freeman BD, Holmes JH, Cairns BA, Suffredini AF. US Critical Illness and Injury Trials Group: Smoke Inhalation-associated Acute Lung Injury (SI-ALI) Investigators (USCIIT-SI-ALI) Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States Hospitals. Chest. 2016 Dec;150(6):1260-1268.
Program Type: USCIIT-SI-ALI DISCOVERY

Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN): Evolution of a content management system for point-of-care clinical decision support
Barwise A, Garcia-Arguello L, Dong Y, Hulyalkar M, Vukoja M, Schultz MJ, Adhikari NK, Bonneton B, Kilickaya O, Kashyap R, Gajic O, Schmickl CN.  Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN): Evolution of a content management system for point-of-care clinical decision support. BMC Med Inform Decis Mak. 2016 Oct 3;16(1):127.
Program Type: CERTAIN DISCOVERY

Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial
Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, Talmor D, Gajic O, Ware LB, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A) Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA. 2016 Jun 14;315(22):2406-14.
Program Type: USCIITG-LIPS-A DISCOVERY

Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial
Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, Talmor D, Gajic O, Ware LB, Gong MN; US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A). Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA. 2016 Jun 14;315(22):2406-14. 
Program Type: USCIITG-LIPS DISCOVERY

A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States
Thomas Z, Bandali F, Sankaranarayanan J, Reardon T, Olsen K. A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States. Crit Care Med. 2015 Dec;43(12):2527-34.
Program Type: DISCOVERY

Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study
Sevransky JE, Checkley W, Herrera P, et al; United States Critical Illness and Injury Trials Group-Critical Illness Outcomes Study Investigators. Protocols and hospital mortality in critically ill patients: the United States Critical Illness and Injury Trials Group critical illness outcomes study. Crit Care Med. 2015 Oct;43(10):2076-2084. doi: 10.1097/CCM.0000000000001157.
Program Type: USCIITG-CIOS DISCOVERY

SpO2/FiO2 ratio on hospital admission is an indicator of early acute respiratory distress syndrome development among patients at risk
Festic E, Bansal V, Kor DJ, Gajic O. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) SpO2/FiO2 ratio on hospital admission is an indicator of early acute respiratory distress syndrome development among patients at risk. J Intensive Care Med. 2015 May;30(4):209-16.
Program Type: USCIITG-LIPS DISCOVERY

Checklist for early recognition and treatment of acute illness: International collaboration to improve critical care practice
Vukoja M, Kashyap R, Gavrilovic S, Dong Y, Kilickaya O, Gajic O. Checklist for early recognition and treatment of acute illness: International collaboration to improve critical care practice. World J Crit Care Med. 2015 Feb 4;4(1):55-61.
Program Type: CERTAIN DISCOVERY

Critical Care Pharmacotherapy Trials Network. A multicenter study of the point prevelance of drug-induced hypotension in the ICU
Kane-Gill SL, LeBlanc JM, Dasta JF, Devabhakthuni S. Critical Care Pharmacotherapy Trials Network. A multicenter study of the point prevelance of drug-induced hypotension in the ICU. Crit Crit Care Med. 2014 Oct; 42(10):2197-2203.
Program Type: DISCOVERY

CERTAIN Investigators. A survey on critical care resources and practices in low- and middle-income countries
Vukoja M, Riviello E, Gavrilovic S, Adhikari NK, Kashyap R, Bhagwanjee S, Gajic O, Kilickaya O. CERTAIN Investigators. A survey on critical care resources and practices in low- and middle-income countries. Glob Heart. 2014 Sep;9(3):337-42.e1-5 
Program Type: CERTAIN DISCOVERY

Obstructive sleep apnea, obesity, and the development of acute respiratory distress syndrome
Karnatovskaia LV, Lee AS, Bender SP, Talmor D, Festic E. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) Obstructive sleep apnea, obesity, and the development of acute respiratory distress syndrome. J Clin Sleep Med. 2014 Jun 15;10(6):657-62.
Program Type: USCIITG-LIPS DISCOVERY

Prehospital use of inhaled corticosteroids and point prevalence of pneumonia at the time of hospital admission: secondary analysis of a multicenter cohort study
Festic E, Bansal V, Gajic O, Lee AS. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Prehospital use of inhaled corticosteroids and point prevalence of pneumonia at the time of hospital admission: secondary analysis of a multicenter cohort study. Mayo Clin Proc. 2014 Feb;89(2):154-62.
Program Type: USCIITG-LIPS DISCOVERY

Structure, Process, and Annual ICU Mortality Across 69 Centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study
Checkley W, Martin GS, Brown SM, et al; United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study Investigators. Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness outcomes study. Crit Care Med. 2014 Feb;42(2):344-56. doi: 10.1097/CCM.0b013e3182a275d7.
Program Type: USCIITG-CIOS DISCOVERY

Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk
Festic E, Ortiz-Diaz E, Lee A, Li G, Kor DJ, Adebola A, Akca O, Hoth J, Levitt JE, Carter R, Gajic O. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. J Crit Care. 2013 Dec;28(6):985-91. 
Program Type: USCIITG-LIPS DISCOVERY

The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes
Karnatovskaia LV, Lee AS, Gajic O, Festic E. U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes. Crit Care Med. 2013 Jul;41(7):1679-85.
Program Type: USCIITG-LIPS DISCOVERY

Sex, race, and the development of acute lung injury
Lemos-Filho LB, Mikkelsen ME, Martin GS, Dabbagh O, Adesanya A, Gentile N, Esper A, Gajic O, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Sex, race, and the development of acute lung injury. Chest. 2013 Apr;143(4):901-909.
Program Type: USCIITG-LIPS DISCOVERY

Contemporary ventilator management in patients with and at risk of ALI/ARDS
Chang SY, Dabbagh O, Gajic O, Patrawalla A, Elie MC, Talmor DS, Malhotra A, Adesanya A, Anderson HL 3rd, Blum JM, Park PK, Gong MN. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Contemporary ventilator management in patients with and at risk of ALI/ARDS. Respir Care. 2013 Apr;58(4):578-88.
Program Type: USCIITG-LIPS DISCOVERY

United States Critical Illness and Injury Trials Group
Blum JM, Morris PE, Martin GS, Gong MN, Bhagwanjee S, Cairns CB, Cobb JP. United States Critical Illness and Injury Trials Group. Chest. 2013 Mar;143(3):808-813.
Program Type: DISCOVERY

Preshospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk
Karnatovskaia LV, Festic E, Gajic O, Carter RE, Lee AS. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Preshospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk. J Crit Care. 2012 Oct;27(5):447-53.
Program Type: USCIITG-LIPS DISCOVERY

Perceived versus actual sedation practices in adult intensive care unit patients receiving mechanical ventilation
Gill KV, Voils SA, Chenault GA, Brophy GM. Perceived versus actual sedation practices in adult intensive care unit patients receiving mechanical ventilation. Ann Pharmacother. 2012 Oct; 46 (10): 1331-9.
Program Type: DISCOVERY

Lung Injury Prevention with Aspirin (LIPS-A): A protocol for a multicenter randomised clinical trial in medical patients at high risk of acute lung injury
Kor DJ, Talmor DS, Banner-Goodspeed VM, Carter RE, Hinds R, Park PK, Gajic O, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A). Lung Injury Prevention with Aspirin (LIPS-A): A protocol for a multicenter randomised clinical trial in medical patients at high risk of acute lung injury. BMJ Open. 2012 Sep 4;2(5).
Program Type: USCIITG-LIPS-A DISCOVERY

Lung injury prediction score for the emergency department: first steps towards prevention in patients at risk
Elie-Turenne MC, Hou PC, Mitani A, Barry JM, Kao EY, Cohen JE, Frendl G, Gajic O, Gentile NT. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS 1.) Lung injury prediction score for the emergency department: first steps towards prevention in patients at risk. Int J Emerg Med. 2012 Sep 3;5(1):33
Program Type: USCIITG-LIPS-1 DISCOVERY

Critical Care Societies Collaborative, USCIITG Task Force on Critical Care Research. Multisociety Task Force for Critical Care Research: Key issues and recommendations
Deutschman CS, Ahrens T, Cairns CB, Sessler CN, Parsons PE. Critical Care Societies Collaborative, USCIITG Task Force on Critical Care Research. Multisociety Task Force for Critical Care Research: Key issues and recommendations. Crit Care Med. 2012 Jan;40
Program Type: DISCOVERY

Critical Illness Outcomes Study: An Observational Study on Protocols and Mortality in Intensive Care Units
Ali NA, Gutteridge D, Shahul S, Checkley W, Sevransky J, Martin GS. Critical Illness Outcomes Study: An Observational Study on Protocols and Mortality in Intensive Care Units. J Clin Trials. 2011 Sep 23;2011(3):55-65.
Program Type: USCIITG-CIOS DISCOVERY

Critical Illness Outcome Study: An Observational Study on Protocols and Mortality in Intensive Care Units
Ali NA, Gutteridge D, Shahul S, Checkley W, Sevransky J, Martin GS. Critical illness outcome study: an observational study on protocols and mortality in intensive care units. Open Access J Clin Trials. 2011 Sep 23;2011(3):55-65. doi: 10.2147/OAJCT.S24223.
Program Type: USCIITG-CIOS DISCOVERY

Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study
Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H 3rd, Hoth JJ, Mikkelsen ME, Gentile NT, Gong MN, Talmor D, Bajwa E, Watkins TR, Festic E, Yilmaz M, Iscimen R, Kaufman DA, Esper AM, Sadikot R, Douglas I, Sevransky J, Malinchoc M . U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011 Feb 15;183(4):462-70.
Program Type: USCIITG-LIPS DISCOVERY

Off-label medication use in adult critical care patients
Lat I, Micek S, Janzen J, Cohen H, Olsen K, Haas C. Off-label medication use in adult critical care patients. J Crit Care. 2011 Feb; 26(1): 89-94.
Program Type: DISCOVERY

The United States critical illness and injury trials group: An introduction
Cobb JP, Cairns CB, Bulger E, Wong HR, Parsons PE, Angus DC, Gentile NT, Hoyt DB, Schwinn DA, Wiener-Kronish JP, Upperman JS. The United States critical illness and injury trials group: an introduction. J Trauma. 2009 Aug;67(2 Suppl):S159-60.
Program Type: DISCOVERY

Towards prevention of acute lung injury: Frequency and outcomes of emergency department patients at-risk – a multicenter cohort study
Hou PC, Elie-Turenne MC, Mitani A, Barry JM, Kao EY, Cohen JE, Frendl G, Gajic O, Gentile NT. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS 1). Towards prevention of acute lung injury: frequency and outcomes of emergency department patients at-risk – a multicenter cohort study. Int J Emerg Med. 2012 May 27;5(1):22.
Program Type: USCIITG-LIPS-1 DISCOVERY