Publications

Discovery, the Critical Care Research Network Publications

Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events
Anesi G, Sevransky J, Cobb J, Evans L. Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events. 2021 Jun.
Program Type: CERTAIN, HEMAIR

The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children with COVID-19
Tripathi S, Christison AL, Levy E, McGravery J, Tekin A, Bolliger D, Kumar VK, Bansal V, Chiotos K, Gist KM, Dapul HR, Bhalala US, Gharpure VP, Heneghan JA, Gupta N, Bjornstad EC, Montgomery VL, Walkey A, Kashyap R, Arteaga GM. The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children with COVID-19. Hosp Pediatr. 2021 Jun 24:e2021006087. doi: 10.1542/hpeds.2021-006087. 
Program Type: CERTAIN, CCPTN

Variation in Early Management Practices in Moderate-to-Severe Acute Respiratory Distress Syndrome in the United States
Qadir N, Bartz RR, Cooter ML, Hough CL, Lanspa MJ, Banner-Goodspeed VM, Chen JT, Giovanni S, Gomaa D, Sjoding MW, Hajizadeh N, Komisarow J, Duggal A, Khanna AK, Kashyap R, Khan A, Chang SY, Tonna JE, Anderson HL 3rd, Liebler JM, Mosier JM, Morris PE, Genthon A, Louh IK, Tidswell M, Stephens RS, Esper AM, Dries DJ, Martinez AA, Schreyer KE, Bender W, Tiwari A, Guru PK, Hanna S, Gong MN, Park PK; SAGE Investigators, on behalf of SCCM Discovery. Variation in Early Management Practices in Moderate-to-Severe Acute Respiratory Distress Syndrome in the United States. Chest. 2021 Jun 2:S0012-3692(21)01078-3. 
Program Type: CERTAIN

Checklist for Early Recognition and Treatment of Acute Illness and Injury: An Exploratory Multicenter International Quality-Improvement Study in the ICUs With Variable Resources
Vukoja M, Dong Y, Adhikari NKJ, Schultz MJ, Arabi YM, Martin-Loeches I, Hache M, Gavrilovic S, Kashyap R, Gajic O; Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN) Investigators of the SCCM Discovery Network and Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN) Investigators. Checklist for Early Recognition and Treatment of Acute Illness and Injury: An Exploratory Multicenter International Quality-Improvement Study in the ICUs With Variable Resources. Crit Care Med. 2021 Jun 1;49(6):e598-e612. 
Program Type: CERTAIN

Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry
Tripathi S, Gist KM, Bjornstad EC, Kashyap R, Boman K, Chiotos K, Gharpure VP, Dapul H, Sayed IA, Kuehne J, Heneghan JA, Gupta M, Khandhar PB, Menon S, Gupta N, Kumar VK, Retford L, Zimmerman J, Bhalala US; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry. Pediatr Crit Care Med. 2021 May 10. 
Program Type: CERTAIN

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial
Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall A, Hinson JS, Hooper MH, Kelen GD, Khan A, Levine MA, Lewis RJ, Lindsell CJ, Marlin JS, McGlothlin A, Moore BL, Nugent KL, Nwosu S, Polito CC, Rice TW, Ricketts EP, Rudolph CC, Sanfilippo F, Viele K, Martin GS, Wright DW; VICTAS Investigators. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. JAMA. 2021 Feb 23;325(8):742-750.
Program Type: CERTAIN

Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry
Domecq JP, Lal A, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Harhay MO, Garcia MA, Kaufman M, Danesh V, Cheruku S, Banner-Goodspeed VM, Anderson HL 3rd, Milligan PS, Denson JL, St Hill CA, Dodd KW, Martin GS, Gajic O, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2021 Mar 1;49(3):437-448.
Program Type: CERTAIN

Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry
Walkey AJ, Sheldrick RC, Kashyap R, Kumar VK, Boman K, Bolesta S, Zampieri FG, Bansal V, Harhay MO, Gajic O. Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2020 Nov;48(11):e1038-e1044.  
Program Type: CERTAIN

Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock
Roberts RJ, Miano TA, Hammond DA, Patel GP, Chen JT, Phillips KM, Lopez N, Kashani K, Qadir N, Cairns CB, Mathews K, Park P, Khan A, Gilmore JF, Brown ART, Tsuei B, Handzel M, Chang AL, Duggal A, Lanspa M, Herbert JT, Martinez A, Tonna J, Ammar MA, Nazer LH, Heavner M, Pender E, Chambers L, Kenes MT, Kaufman D, Downey A, Brown B, Chaykosky D, Wolff A, Smith M, Nault K, Gong MN, Sevransky JE, Lat I; Observation of VariatiOn in fLUids adMinistEred in shock-CHaracterizAtion of vaSoprEssor Requirements in Shock (VOLUME-CHASERS) Study Group and SCCM Discovery Network. Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock. Crit Care Med. 2020 Oct;48(10):1445-1453.  
Program Type: CERTAIN

Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study
Smischney NJ, Khanna AK, Brauer E, Morrow LE, Ofoma UR, Kaufman DA, Sen A, Venkata C, Morris P, Bansal V. Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study. J Intensive Care Med. 2020 Oct 1:885066620962445. 
Program Type: CERTAIN

Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study
Smischney NJ, Kashyap R, Khanna AK, Brauer E, Morrow LE, Seisa MO, Schroeder DR, Diedrich DA, Montgomery A, Franco PM, Ofoma UR, Kaufman DA, Sen A, Callahan C, Venkata C, Demiralp G, Tedja R, Lee S, Geube M, Kumar SI, Morris P, Bansal V, Surani S; SCCM Discovery (Critical Care Research Network of Critical Care Medicine) HEMAIR Investigators Consortium. Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study. PLoS One. 2020 Aug 31;15(8):e0233852. 
Program Type: CERTAIN

Effectiveness of a Daily Rounding Checklist on Processes of Care and Outcomes in Diverse Pediatric Intensive Care Units Across the World
Kashyap R, Murthy S, Arteaga GM, Dong Y, Cooper L, Kovacevic T, Basavaraja C, Ren H, Qiao L, Zhang G, Sridharan K, Jin P, Wang T, Tuibeqa I, Kang A, Ravi MD, Ongun E, Gajic O, Tripathi S; SCCM Discovery CERTAINp Collaborative Investigators. Effectiveness of a Daily Rounding Checklist on Processes of Care and Outcomes in Diverse Pediatric Intensive Care Units Across the World. J Trop Pediatr. 2020 Aug 27:fmaa058. 
Program Type: CERTAIN

The Viral Infection and Respiratory Illness Universal Study (VIRUS): An International Registry of Coronavirus 2019-Related Critical Illness
Walkey AJ, Kumar VK, Harhay MO, Bolesta S, Bansal V, Gajic O, Kashyap R. The Viral Infection and Respiratory Illness Universal Study (VIRUS): An International Registry of Coronavirus 2019-Related Critical Illness. Crit Care Explor. 2020 Apr 29;2(4):e0113.  
Program Type: CERTAIN

Current practices and safety of medication use during rapid sequence intubation
Groth C, Acquisto NM, Khadem T.  Current practices and safety of medication use during rapid sequence intubation:  A multicenter study evaluating practices across the United States.  J Crit Care  2018;45:65-70. Epub 2018 Jan 30.
Program Type: CERTAIN

Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients
Seethala RR, Hou PC, Aisiku IP, Frendl G, Park PK, Mikkelsen ME, Chang SY, Gajic O, Sevransky J. Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients. Ann Intensive Care. 2017 Dec;7(1):11.
Program Type: CERTAIN, CCPTN, HEMAIR

Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome
Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE. Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May;45(5):798-805.
Program Type: CERTAIN

(USCIIT-SI-ALI) Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States Hospitals
Kadri SS, Miller AC, Hohmann S, Bonne S, Nielsen C, Wells C, Gruver C, Quraishi SA, Sun J, Cai R, Morris PE, Freeman BD, Holmes JH, Cairns BA, Suffredini AF. US Critical Illness and Injury Trials Group: Smoke Inhalation-associated Acute Lung Injury (SI-ALI) Investigators (USCIIT-SI-ALI) Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States Hospitals. Chest. 2016 Dec;150(6):1260-1268.
Program Type: CERTAIN

Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN): Evolution of a content management system for point-of-care clinical decision support
Barwise A, Garcia-Arguello L, Dong Y, Hulyalkar M, Vukoja M, Schultz MJ, Adhikari NK, Bonneton B, Kilickaya O, Kashyap R, Gajic O, Schmickl CN.  Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN): Evolution of a content management system for point-of-care clinical decision support. BMC Med Inform Decis Mak. 2016 Oct 3;16(1):127.
Program Type: CERTAIN

(USCIITG: LIPS-A) Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial
Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, Talmor D, Gajic O, Ware LB, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A) Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA. 2016 Jun 14;315(22):2406-14.
Program Type: CERTAIN

Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial
Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, Talmor D, Gajic O, Ware LB, Gong MN; US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A). Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA. 2016 Jun 14;315(22):2406-14. 
Program Type: USCIITG-LIPS

A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States
Thomas Z, Bandali F, Sankaranarayanan J, Reardon T, Olsen K. A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States. Crit Care Med. 2015 Dec;43(12):2527-34.
Program Type: CERTAIN

(USCIITG–LIPS) SpO2/FiO2 ratio on hospital admission is an indicator of early acute respiratory distress syndrome development among patients at risk
Festic E, Bansal V, Kor DJ, Gajic O. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) SpO2/FiO2 ratio on hospital admission is an indicator of early acute respiratory distress syndrome development among patients at risk. J Intensive Care Med. 2015 May;30(4):209-16.
Program Type: CERTAIN

Checklist for early recognition and treatment of acute illness: International collaboration to improve critical care practice
Vukoja M, Kashyap R, Gavrilovic S, Dong Y, Kilickaya O, Gajic O. Checklist for early recognition and treatment of acute illness: International collaboration to improve critical care practice. World J Crit Care Med. 2015 Feb 4;4(1):55-61.
Program Type: CERTAIN

Critical Care Pharmacotherapy Trials Network. A multicenter study of the point prevelance of drug-induced hypotension in the ICU
Kane-Gill SL, LeBlanc JM, Dasta JF, Devabhakthuni S. Critical Care Pharmacotherapy Trials Network. A multicenter study of the point prevelance of drug-induced hypotension in the ICU. Crit Crit Care Med. 2014 Oct; 42(10):2197-2203.
Program Type: CERTAIN

CERTAIN Investigators. A survey on critical care resources and practices in low- and middle-income countries
Vukoja M, Riviello E, Gavrilovic S, Adhikari NK, Kashyap R, Bhagwanjee S, Gajic O, Kilickaya O. CERTAIN Investigators. A survey on critical care resources and practices in low- and middle-income countries. Glob Heart. 2014 Sep;9(3):337-42.e1-5 
Program Type: CERTAIN

(USCIITG–LIPS) Obstructive sleep apnea, obesity, and the development of acute respiratory distress syndrome
Karnatovskaia LV, Lee AS, Bender SP, Talmor D, Festic E. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) Obstructive sleep apnea, obesity, and the development of acute respiratory distress syndrome. J Clin Sleep Med. 2014 Jun 15;10(6):657-62.
Program Type: CERTAIN

(USCIITG-LIPS) Prehospital use of inhaled corticosteroids and point prevalence of pneumonia at the time of hospital admission: secondary analysis of a multicenter cohort study
Festic E, Bansal V, Gajic O, Lee AS. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Prehospital use of inhaled corticosteroids and point prevalence of pneumonia at the time of hospital admission: secondary analysis of a multicenter cohort study. Mayo Clin Proc. 2014 Feb;89(2):154-62.
Program Type: CERTAIN

(USCIITG-LIPS) Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk
Festic E, Ortiz-Diaz E, Lee A, Li G, Kor DJ, Adebola A, Akca O, Hoth J, Levitt JE, Carter R, Gajic O. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. J Crit Care. 2013 Dec;28(6):985-91. 
Program Type: CERTAIN

(USCIITG–LIPS) The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes
Karnatovskaia LV, Lee AS, Gajic O, Festic E. U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes. Crit Care Med. 2013 Jul;41(7):1679-85.
Program Type: CERTAIN

(USCIITG-LIPS) Sex, race, and the development of acute lung injury
Lemos-Filho LB, Mikkelsen ME, Martin GS, Dabbagh O, Adesanya A, Gentile N, Esper A, Gajic O, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Sex, race, and the development of acute lung injury. Chest. 2013 Apr;143(4):901-909.
Program Type: CERTAIN

(USCIITG-LIPS) Contemporary ventilator management in patients with and at risk of ALI/ARDS
Chang SY, Dabbagh O, Gajic O, Patrawalla A, Elie MC, Talmor DS, Malhotra A, Adesanya A, Anderson HL 3rd, Blum JM, Park PK, Gong MN. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Contemporary ventilator management in patients with and at risk of ALI/ARDS. Respir Care. 2013 Apr;58(4):578-88.
Program Type: CERTAIN

United States Critical Illness and Injury Trials Group
Blum JM, Morris PE, Martin GS, Gong MN, Bhagwanjee S, Cairns CB, Cobb JP. United States Critical Illness and Injury Trials Group. Chest. 2013 Mar;143(3):808-813.
Program Type: CERTAIN

(USCIITG-LIPS) Preshospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk
Karnatovskaia LV, Festic E, Gajic O, Carter RE, Lee AS. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Preshospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk. J Crit Care. 2012 Oct;27(5):447-53.
Program Type: CERTAIN

Perceived versus actual sedation practices in adult intensive care unit patients receiving mechanical ventilation
Gill KV, Voils SA, Chenault GA, Brophy GM. Perceived versus actual sedation practices in adult intensive care unit patients receiving mechanical ventilation. Ann Pharmacother. 2012 Oct; 46 (10): 1331-9.
Program Type: CERTAIN

Lung Injury Prevention with Aspirin (LIPS-A): A protocol for a multicenter randomised clinical trial in medical patients at high risk of acute lung injury
Kor DJ, Talmor DS, Banner-Goodspeed VM, Carter RE, Hinds R, Park PK, Gajic O, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A). Lung Injury Prevention with Aspirin (LIPS-A): A protocol for a multicenter randomised clinical trial in medical patients at high risk of acute lung injury. BMJ Open. 2012 Sep 4;2(5).
Program Type: USCIITG-LIPS

Lung injury prediction score for the emergency department: first steps towards prevention in patients at risk
Elie-Turenne MC, Hou PC, Mitani A, Barry JM, Kao EY, Cohen JE, Frendl G, Gajic O, Gentile NT. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS 1.) Lung injury prediction score for the emergency department: first steps towards prevention in patients at risk. Int J Emerg Med. 2012 Sep 3;5(1):33
Program Type: USCIITG-LIPS

Critical Care Societies Collaborative, USCIITG Task Force on Critical Care Research. Multisociety Task Force for Critical Care Research: Key issues and recommendations
Deutschman CS, Ahrens T, Cairns CB, Sessler CN, Parsons PE. Critical Care Societies Collaborative, USCIITG Task Force on Critical Care Research. Multisociety Task Force for Critical Care Research: Key issues and recommendations. Crit Care Med. 2012 Jan;40
Program Type: CERTAIN

Critical Illness Outcomes Study: An Observational Study on Protocols and Mortality in Intensive Care Units
Ali NA, Gutteridge D, Shahul S, Checkley W, Sevransky J, Martin GS. Critical Illness Outcomes Study: An Observational Study on Protocols and Mortality in Intensive Care Units. J Clin Trials. 2011 Sep 23;2011(3):55-65.
Program Type: CERTAIN

Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study
Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H 3rd, Hoth JJ, Mikkelsen ME, Gentile NT, Gong MN, Talmor D, Bajwa E, Watkins TR, Festic E, Yilmaz M, Iscimen R, Kaufman DA, Esper AM, Sadikot R, Douglas I, Sevransky J, Malinchoc M . U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011 Feb 15;183(4):462-70.
Program Type: CERTAIN

Off-label medication use in adult critical care patients
Lat I, Micek S, Janzen J, Cohen H, Olsen K, Haas C. Off-label medication use in adult critical care patients. J Crit Care. 2011 Feb; 26(1): 89-94.
Program Type: CERTAIN

The United States critical illness and injury trials group: An introduction
Cobb JP, Cairns CB, Bulger E, Wong HR, Parsons PE, Angus DC, Gentile NT, Hoyt DB, Schwinn DA, Wiener-Kronish JP, Upperman JS. The United States critical illness and injury trials group: an introduction. J Trauma. 2009 Aug;67(2 Suppl):S159-60.
Program Type: CERTAIN

Towards prevention of acute lung injury: Frequency and outcomes of emergency department patients at-risk – a multicenter cohort study
Hou PC, Elie-Turenne MC, Mitani A, Barry JM, Kao EY, Cohen JE, Frendl G, Gajic O, Gentile NT. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS 1). Towards prevention of acute lung injury: frequency and outcomes of emergency department patients at-risk – a multicenter cohort study. Int J Emerg Med. 2012 May 27;5(1):22.
Program Type: USCIITG-LIPS