Use of Factor Concentrates in Critically Ill Patients

Explore the current landscape of factor concentrate use and how they compare to plasma and cryoprecipitate transfusions.

Webcast

Use of Factor Concentrates in Critically Ill Patients

Tuesday, November 4, 2025

1:00 p.m. – 2:00 p.m. Central Time
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Factor concentrates are increasingly used in place of traditional blood products for managing bleeding in critically ill patients. This webcast will explore the current landscape of factor concentrate use—including prothrombin complex concentrate (PCC), fibrinogen concentrate, and recombinant activated factor VII (rFVIIa)—and how they compare to plasma and cryoprecipitate transfusions. 

Expert panelists will discuss recent clinical trial data, evolving dosing strategies, and the risks and benefits of these therapies across three high-risk patient populations: trauma, cardiac surgery, and liver transplantation. Participants will gain a deep understanding of how these products are being integrated into modern hemostatic protocols and their potential to improve outcomes in critical care settings.

Participants can earn 1 accredited continuing education (ACE) credit and maintenance of certification (MOC) point. This webcast is held in partnership with SCCM's Anesthesiology Section.

Tuesday, November 4, 2025
1:00 p.m. – 2:00 p.m. Central Time

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Learning Objectives

  • Describe the potential risks and benefits of prothrombin complex concentrate (PCC), fibrinogen concentrate, and recombinant activated factor VII (rFVIIa) in patients with multitrauma and major hemorrhage
  • Summarize the data from recent clinical trials for the use of PCC, fibrinogen concentrate, and rFVIIa in cardiac surgical patients
  • Discuss the risks and benefits of PCC, fibrinogen concentrate, and rFVIIa in patients undergoing liver transplantation who have major hemorrhage

SUBJECT MATTER EXPERT

Amber N. Campbell, MD, MS

Staff Anesthesiologist
Red Bank Anesthesia
Red Bank, New Jersey, USA 

SUBJECT MATTER EXPERT

John C. Klick, MD, FCCM

Professor of Anesthesiology 
University of Vermont Medical Center 
Burlington, Vermont, USA

SUBJECT MATTER EXPERT

Akhil Patel, MD

Assistant Professor of Anesthesiology and Critical Care Medicine
George Washington University Hospital
Washington, DC, USA

MODERATOR

Michael Mazzeffi, MD, MPH, FCCM

Cardiothoracic Anesthesiologist
University of Virginia
Charlottesville, Virginia, USA

Member Discounts

SCCM members receive FREE registration for these webcasts. Join SCCM or upgrade your membership at any time.

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