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Concise Critical Appraisal: Cerebral Oxygen Metabolism and RBC Transfusion in Infants

Neunhoeffer et al (Pediatr Crit Care Med. 2018;19:318-327) sought to use noninvasive means to determine the changes in cerebral oxygen metabolism in infants younger than 6 months who have undergone major surgery.  


SCCM Pod-397 Renal Recovery After Critical Illness

Ludwig H. Lin, MD, and John A. Kellum, MD, MCCM, review factors associated with renal recovery, therapies and techniques used to enhance recovery, and long-term consequences of nonrecovery in critical illness.


Concise Critical Appraisal: Epinephrine in Out-of-Hospital Cardiac Arrest

Perkins et al (N Engl J Med. 2018;379:711-721) set out to examine the effects of epinephrine during OHCA.


SCCM Pod-403 Sepsis: The Hour-1 Bundle, the Future of Research, and More

Margaret M. Parker, MD, MCCM, and Mitchell M. Levy, MD, MCCM discuss the Hour-1 Bundle, the controversies of the Surviving Sepsis Campaign, and the future of sepsis.


Concise Critical Appraisal: Fluid Administration and Diabetic Ketoacidosis

Kuppermann et al (N Engl J Med. 2018;378:2275-2287) sought to prospectively determine the role that fluid makeup and rate have on the development of neurologic injury in children with DKA.


SCCM Pod-414 COVID-19 VIRUS Registry Aims to Identify Effective Treatment Strategies

Discovery, the Critical Care Research Network's Viral Infection and Respiratory Illness Universal Study creates a real-time COVID-19 registry of current ICU and hospital care patterns.


Concise Critical Appraisal: The Effect of Ramelteon Administration on the Duration of ICU Stay

Nishikimi et al (Crit Care Med. 2018;46:1099-1105) set out to identify the effects of ramelteon, a melatonin agonist, on ICU length of stay for critically ill patients.


Concise Critical Appraisal: The Efficacy of ECMO for Severe ARDS

Combes et al (N Engl J Med. 2018;378:1965-1975) set out to determine whether the use of ECMO reduced mortality in patients with ARDS when defined by one of three criteria: P/F ratio < 50 mm Hg for > 3 hours, P/F ratio < 80 mm Hg for > 6 hours, or pH < 7.25 coupled with Paco2 ≥ 60 mm Hg for > 6 hours (with respiratory rate < 35 beats/min and plateau pressure ≤ 32 cm H2O). 


Concise Critical Appraisal: Ultra-Low Tidal Volume Ventilation During CPR

Ruemmler et al (Resuscitation. 2018;132:56-62) set out to compare intermittent positive pressure ventilation to passive oxygenation (continuous positive airway pressure) and a novel ultra-low tidal volume ventilation (ULTVV) regimen.


Help Shape the Future of Sepsis Research on the National Level

The National Institute of General Medical Sciences (NIGMS) is changing its priorities to invest in sepsis research in a more targeted and strategic way. In an important opportunity to help shape the future of sepsis research, NIGMS has issued a request for information related to its new priorities. The request for information is found here and is due by November 15, 2019.


ICU-Telemedicine May Reduce Death

Intensive care unit (ICU) patients who receive services via telemedicine are less likely to die and more likely to leave the hospital sooner compared with those receiving traditional ICU care, suggests a large study being presented at the Society of Critical Care Medicine’s 50th Critical Care Congress.