Adult Sepsis Guidelines
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Determine the safest, most effective approach to sepsis intervention.
The Assessment of Implementation of Methods in Sepsis and Respiratory Failure (AIMS) study seeks to determine the safest and most effective approach to sepsis intervention using the evidence-based Surviving Sepsis Campaign (SSC) guidelines. The five-year prospective multicenter study is being funded by a $3.2 million grant awarded to Rhode Island Hospital in Providence, Rhode Island, from the National Heart, Lung, and Blood Institute. The Society of Critical Care Medicine (SCCM) serves as the data and clinical coordinating center for the study.
The goal of the AIMS study is to determine whether the Hour-1 Bundle or 3-Hour Bundle is most effective when implemented in emergency departments. The AIMS study compares both bundles head to head for the first time since they were developed by the SSC. The study is being conducted at 18 U.S. hospitals, including both community and academic hospitals. It will ultimately include about 10,000 patients eligible for sepsis care who will receive either the Hour-1 or 3-Hour Bundle.
The steps of the 3-Hour Bundle should be completed within three hours. The steps of the Hour-1 Bundle should be started within the first hour. While the Hour-1 Bundle has been adopted by some hospitals, the 3-Hour Bundle is the current standard of care in the United States and is mandated by the Centers for Medicaid and Medicare.
The National Institutes of Health funding is a T3 translational research grant, which seeks to ensure that evidence-based interventions and treatments are delivered effectively. Staff in both the Hour-1 and 3-Hour bundle arms will be trained in techniques for enhancing integration of either bundle into practice by implementation scientists from Brown University.
The study’s primary outcome is hospital mortality. Secondary outcomes include:
Professor of Medicine
System-Wide Director, Critical Care, Lifespan Systems
Rhode Island Hospital
Providence, Rhode Island, USA