SCCM Pod-165 PCCM: PAI-1 May Lead to Early Diagnosis of VAP in Children

Ramya Srinivasan, MD, discusses her article published in the January Pediatric Critical Care Medicine titled, “Plasminogen Activation Inhibitor Concentrations in Bronchoalveolar Lavage Fluid Distinguishes Ventilator-Associated Pneumonia from Colonization in Mechanically Ventilated Pediatric Patients.” The article found that PAI-1 discriminated well between pediatric patients diagnosed clinically with VAP compared with those who were considered colonized. This resulted in PAI-1 being useful in directing appropriate antibiotic therapy in intubated patients suspected of having a new pulmonary infection. Srinivasan is a pediatric intensivist at Sutter Memorial Hospital in Sacramento and a translational researcher at the University of California in San Francisco.

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Category: PCCM Podcast