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Category: Sepsis

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SCCM Pod-406 Surviving Sepsis Campaign Children's Guidelines

Margaret M. Parker, MD, MCCM, and Scott L. Weiss, MD, FCCM, discuss the release of "Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children," published in the February 2020 issue of Pediatric Critical Care Medicine (Weiss S, et al. Pediatr Crit Care Med. 2020;21(2);e52-e106).

Dr. Weiss outlines the differences between the new pediatric Surviving Sepsis Campaign (SSC) guidelines and the 2017 “American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock” (Davis AL, et al. Crit Care Med. 2017;45:1061-1093), as well as key differences from the “Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016” (Rhodes A, et al. Crit Care Med. 2017;45:486-552).

The challenges in implementing the pediatric guidelines in resource-limited areas and key recommendations for resuscitation of children with sepsis and septic shock are also covered.

Dr. Weiss has served as the SCCM-appointed co-vice-chair of the SSC Guidelines Task Force. He is an attending physician at the Children’s Hospital of Philadelphia.


SCCM Pod-403 Sepsis: The Hour-1 Bundle, the Future of Research, and More

Margaret M. Parker, MD, MCCM, and Mitchell M. Levy, MD, MCCM discuss the Hour-1 Bundle, the controversies of the Surviving Sepsis Campaign, and the future of sepsis. Drs. Parker and Levy go beyond the bundle to talk about the challenges of the Campaign from data entry to resistance from physicians, sepsis in resource limited countries, and spreading quality improvement worldwide. Dr. Levy is professor of medicine and chief of pulmonary and critical care at Brown University in Providence, Rhode Island, USA. This podcast is part 5 of a series sponsored by Baxter Healthcare Corporation.


SCCM Pod-377 Procalcitonin Guidance in Patients with Sepsis

Ludwig H. Lin, MD, and Philipp Schuetz, MD, discuss procalcitonin and how it impacts treatment of sepsis. This podcast originated from the article "Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis" (Iankova I, et al. Crit Care Med. 2018;46:691-698).

Dr. Schuetz is a professor of internal medicine, endocrinology, diabetes, and metabolism at the University of Basel in Basel, Switzerland.

This podcast is sponsored by Thermo Fisher Scientific.


SCCM Pod-369 Hospital Variation in Risk-Adjusted Pediatric Sepsis Mortality

Margaret Parker, MD, MCCM, speaks with Stefanie G. Ames, MD, about the article “Hospital Variation in Risk-Adjusted Pediatric Sepsis Mortality,” published in the May 2018 issue of Pediatric Critical Care Medicine.

Dr. Ames discusses study findings regarding the development of a method to evaluate hospital pediatric sepsis performance and how to assess hospital variation in risk-adjusted sepsis mortality in a large state-wide sample.

Dr. Ames is a pediatric critical care fellow at the University of Pittsburg School of Medicine in Pittsburg, Pennsylvania.

She is working with the Clinical Research Investigation and Systems Modeling of Acute Illness (CRISMA) Center in the department of critical care medicine. Ped Crit Care Med. 2018; 19(5):390-396.


SCCM Pod-363 Hemodynamic Support of Pediatric and Neonatal Septic Shock

Margaret Parker, MD, MCCM, speaks with Joseph A. Carcillo, MD, about the article, "American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock," published in the June 2017 issue of Critical Care Medicine. Dr. Carcillo the revisions made to the 2014 guidelines and recommendations regarding use of 1) a “recognition bundle” containing a trigger tool for rapid identification of patients with septic shock, 2) a “resuscitation and stabilization bundle” to help adherence to best practice principles, and 3) a “performance bundle” to identify and overcome perceived barriers to the pursuit of best practice principles. Dr. Carcillo is a professor of Anesthesia, Critical Care Medicine, and Pediatrics at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania. Crit Care Med. 2017; 45(6):1061-1093. Published: 6/7/2018


SCCM Pod-355 The Epidemiology of Hospital Death Following Pediatric Severe Sepsis

Margaret Parker, MD, MCCM, speaks with Scott L. Weiss, MD, MSCE, about the article, “The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die,” published in the September 2017 issue of Pediatric Critical Care Medicine. Dr. Weiss discusses research findings regarding when, why, and the mode in which children with sepsis die, and how understanding these factors are important in setting appropriate clinical and research priorities. Dr. Weiss is an Assistant Professor in the Division of Critical Care Medicine in the Department of Anesthesiology and Critical Care at The Children’s Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine in Philadelphia, Pennsylvania. Pediatr Crit Care Med. 2017; 18(9):823-830. Released: 12/7/17


SCCM Pod-354 The Septic Shock 3.0 Definition and Trials

Ranjit Deshpande, MD, speaks with James A. Russell, MD, about the article, “The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience,” published in the June 2017 issue of Critical Care Medicine. Dr. Russell discusses findings from his retrospective analysis of the Vasopressin and Septic Shock Trial (VASST) using the Septic Shock 3.0 definition, and implications for trial design in septic shock. Dr. Russell is a professor of medicine at the University of British Columbia, and principal investigator at the Centre for Heart Lung Innovation at St. Paul’s Hospital in Vancouver, BC, Canada. Crit Care Med. 2017; 45(6):940-948. Released: 11/16/17


SCCM Pod-346 Delays in Antibiotic Administration for Sepsis

Todd Fraser, MD, speaks with Christopher W. Seymour, MD, MSc, about the article, “Delays From First Medical Contact to Antibiotic Administration for Sepsis,” published in Critical Care Medicine. Dr. Seymour's article contends that "the time from first healthcare contact to antibiotic administration in sepsis, termed 'total medical contact delay,'" is not fully understood. He discusses the association between total medical contact delay and in-hospital mortality among community-acquired sepsis patients in a large retrospective cohort. He also discusses strategies to help reduce delays. Dr. Seymour is Assistant Professor of Critical Care and Emergency Medicine at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania. He is also a core faculty member in the Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center in the Department of Critical Care, where he contributes to the Program on Critical Care Health Policy. Crit Care Med. 2017; 45(5):759-765. Released: 8/10/17


SCCM Pod-336 Surviving Sepsis Campaign Guidelines: 2016 Update

Ludwig Lin, MD, speaks with Mitchell M. Levy, MD, MCCM, about the release of the “Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016,” presented at the 46th Critical Care Congress in Honolulu, Hawaii. Dr. Levy is Professor of Medicine and the Division Chief of Pulmonary and Critical Care Medicine at Brown University School of Medicine in Providence, Rhode Island. He has no relevant disclosures. Download the new Surviving Sepsis Guidelines as well as User Guide and other tools for implementation at www.survivingsepsis.org. Crit Care Med. 2017; 45(3):486-552.


SCCM Pod-327 Does Simulation Improve Recognition and Management of Pediatric Septic Shock?

Margaret Parker, MD, MCCM, speaks with Mark C. Dugan, MD, about the article, “Does Simulation Improve Recognition and Management of Pediatric Septic Shock, and If One Simulation Is Good, Is More Simulation Better?” published in the July 2016 issue of Pediatric Critical Care Medicine. Dr. Dugan works as an Attending Pediatric Intensivist at the Children’s Hospital of Nevada at the University Medical Center and as a Clinical Assistant Professor in the Department of Pediatrics at the University of Nevada School of Medicine in Las Vegas, Nevada. In this article, Dr. Dugan and coauthors explore whether or not simulation can be used to assist resident trainees in identifying and performing well at the recognition and management of a critically ill child


SCCM Pod-326 Surviving Sepsis Campaign: Creating Spread for Quality Improvement

Ludwig Lin, MD, speaks with Jane Taylor, Ed.D, about quality improvement science and her contributions to the Surviving Sepsis Campaign. Dr. Taylor is Improvement Advisor to various institutions including the Institute for Healthcare Improvement and SCCM. 


SCCM Pod-300 Timing of Death in Children Referred for Intensive Care with Severe Sepsis

Margaret Parker, MD, MCCM, speaks with Mirjana Cvetkovic, FRCA, about the article, “Timing of Death in Children Referred for Intensive Care with Severe Sepsis: Implications for Interventional Studies,” published in the June 2015 issue of Pediatric Critical Care Medicine. Dr. Cvetkovic works as a Clinical Fellow at the Children’s Acute Transport Service at Great Ormond Street Hospital in London and a Consultant Intensivist in Anesthesia at Leicester Hospital. In this article, Dr. Cvetkovic and coauthors examine the estimator of pediatric septic deaths and the challenges local hospitals are presented with when treating children with sepsis. UPDATE: Cvetkovic notes that CATS has had extensive outreach education for many years. Reference - http://site.cats.nhs.uk/wp-content/uploads/2013/07/cats_annual_reportvers2.4.pdf


SCCM Pod-246 Interaction Between Fluids and Vasoactive Agents on Mortality in Septic Shock

Todd Fraser, MD, speaks with Allan Garland, MD, about the article, “Interaction Between Fluids and Vasoactive Agents on Mortality in Septic Shock: A Multicenter, Observational Study,” published in Critical Care Medicine. Dr. Garland is the co-head of the Section of Critical Care Medicine at the University of Manitoba in Winnipeg, Canada. In this article, Dr. Garland and coauthors examine best practices in administering fluids and vasoactive agents, both common treatments of septic shock, and how these treatments interact.


SCCM Pod-245 Neonatal-Specific Consensus Definition for Sepsis

Margaret Parker, MD, MCCM, speaks with James L. Wynn, MD, about the article, “Time for a Neonatal-Specific Consensus Definition for Sepsis,” published in Pediatric Critical Care Medicine. Dr. Wynn is an Assistant Professor of Pediatrics in the Department of Pediatrics, the Division of Neonatal-Perinatal Medicine, at Vanderbilt University in Nashville, Tennessee. In this article, Dr. Wynn and coauthors review the accuracy of the pediatric consensus definition of sepsis, specifically relating to term neonates and preterm neonates.


SCCM Pod-229: Lifetime Achievement Award, Sepsis Research

Michael Weinstein, MD, FACS, FCCP, speaks with Mitchell P. Fink, MD, FCCM, who is the recipient of the Society of Critical Care Medicine’s Lifetime Achievement Award; he discusses his background in critical care as well as his research endeavors in sepsis in addition to the future of this disease. Dr. Fink is Vice Chair of the Department of Surgery at the David Geffen School of Medicine at UCLA, and Co-Director of the Multidisciplinary Program for Critical Care Medicine at Ronald Reagan UCLA Medical Center in Los Angeles, California, USA. He also serves as Professor in Residence in the Department of Surgery and the Department of Anesthesiology at UCLA.


SCCM Pod-227 Highlights from the Surviving Sepsis Campaign Guidelines

Jeffrey Guy, MD, MSc, MMHC, speaks with R. Phillip Dellinger, MD, MCCM, co-chair of the updated Surviving Sepsis Campaign Guidelines. In a must-listen interview for those implementing the Surviving Sepsis Campaign guidelines, Dr. Dellinger discusses guideline highlights as well as significant changes from the previous guideline and bundles. Dr. Dellinger is Chair and Chief, Department of Medicine, Cooper University Hospital, Camden, New Jersey. More information about the Surviving Sepsis Campaign is available at www.survivingsepsis.org.


SCCM Pod-214 CCM: Benchmarking Severe Sepsis

Michael Weinstein, MD, FACS, FCCP, speaks with David F. Gaieski, MD, lead author on an article published in the May Critical Care Medicine titled, “Benchmarking the Incidence and Mortality of Severe Sepsis in the United States.” The study found that there is substantial variability in incidence and mortality of severe sepsis depending on the method of database abstraction used (Angus, Martin, Dombrovskiy, Wang). Dr. Gaieski is an assistant professor in the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, Pennsylvania, USA.


SCCM Pod-213 Implementing the Surviving Sepsis Campaign Guidelines

Jeffrey Guy, MD, MSc, MMHC, speaks with Christa A. Schorr, RN, MSN, FCCM, who is with us today to discuss implementing the Surviving Sepsis Campaign (SSC) guidelines. Schorr offers suggestions and key points for implementing SSC protocols in the hospital, as well as tips to gain administrative support for implementation. Dr. Schorr is the Director of Databases for Quality Improvement and Research and Program Director of Critical Care Research Trials at Cooper Hospital University Medical Center in Camden, New Jersey. She was also an active member on the 2012 Surviving Sepsis Campaign guidelines.


SCCM Pod-185 PCCM: Defining Pediatric Sepsis

Margaret Parker, MD, FCCM, associate podcast editor, speaks with Denise M. Goodman, MD, MS, about her article published in the July Pediatric Critical Care Medicine, “Defining Pediatric Sepsis by Different Criteria: Discrepancies in Populations and Implications for Clinical Practice.” Goodman is an attending physician in the pediatric intensive care unit at Children’s Memorial Hospital in Chicago, Illinois. She is also an associate professor of pediatrics at Northwestern University Feinberg School of Medicine.


SCCM Pod-175 CCM: Poverty and Bloodstream Infections

Michael S. Weinstein, MD, FACS, FCCP, speaks with Kenneth Christopher, MD, about his paper published in the May 2012 Critical Care Medicine, “Relationship Between Neighborhood Poverty Rate and Bloodstream Infections in the Critically Ill.” Christopher is the assistant director of the Preliminary Residency Program and the assistant program director of the Medicine Residency Program at Brigham and Women’s Hospital in Boston, Massachusetts, USA.