The April 2024 issue features articles investigating immunocompromised-associated pediatric acute respiratory distress syndrome, use of formal ethics consultation in patients undergoing extracorporeal membrane oxygenation (ECMO), measuring hemodynamics and end-tidal carbon dioxide monitoring in extracorporeal cardiopulmonary resuscitation, and insights into the Child Opportunity Index and pediatric intensive care outcomes. Clinical investigations evaluate airway management in children with trisomy 21, iron deficiency in children with anemia who survive critical illness, use of point-of-care ultrasound during mechanical ventilation in patients with dengue shock syndrome, and pediatric sepsis phenotypes and outcomes. This issue also includes a brief report exploring functional status and ECMO candidacy, a special article evaluating machine learning applications in pediatric critical care research, and an online Pediatric Critical Care (PCCM) perspective on study designs for future sedation research. The neurocritical care article offers insights into differences between neurosurgeons and intensivists in decision-making for platelet and plasma transfusion with intracranial monitor placement.