The August issue of Pediatric Critical Care Medicine (PCCM) features articles on how management strategies that change after echocardiography improve outcomes in critically ill children, rapid whole genome-sequencing to facilitate timely genetic diagnosis and clinical prognostication, and a secondary analysis of the ADAPT trial to compare levetiracetam and phenytoin in patients with status epilepticus and traumatic brain injury. The clinical investigations examine chest compression depth targets, clinical outcomes in children with a single ventricle after tracheostomy, changes in inhaled nitric oxide use across intensive care units after implementing a standard approach, and outcomes of severe acute kidney injury in children with acute liver failure. The PCCM trial is a randomized controlled trial comparing high-flow nasal cannula to nasal prong bubble continuous positive airway pressure in children with moderate to severe bronchiolitis, and the neurocritical care article compares four definitions of acute brain dysfunction in pediatric sepsis and septic shock.