This month’s issue features articles on assessing physical, emotional/behavioral, and neurocognitive developmental outcomes in children after pediatric ICU admission, neurologic dysfunction relative to timing of recognition of pediatric sepsis, and using social determinants of health to identify neighborhoods where children are at risk for acute respiratory failure requiring mechanical ventilation. Additionally, there are interesting articles assessing peripheral vasoactive infusions in children with shock, an article investigating pathogen type and outcomes of septic shock, and a comparison of multisystem inflammatory syndrome in children with original/alpha versus delta variants of COVID-19.