This month’s issue features four diverse articles. One explores the interpretation of Von Willebrand factor multimers, concentration, and function in patients on extracorporeal membrane oxygenation (ECMO); another investigates the prevalence of mental health and emotional disorders among pediatric intensive care unit (PICU) staff during the COVID-19 pandemic. There is an article assessing neurocognitive, psychosocial, and quality-of-life outcomes in pediatric patients with multisystem inflammatory syndrome in children who were admitted to the PICU, and another reviewing social determinants of health in children with sepsis. Clinical investigations explore the epidemiology of unplanned extubations, a machine model to track clinical deterioration in hospitalized patients, and multiple organ dysfunction syndrome in children with acute myeloid leukemia. Trials and brief reports investigate obtaining assent for PICU research studies, the Cardiohelp ECMO system, and continuous venovenous hemofiltration in neonates with fluid overload.