Concise Critical Appraisal: Dexamethasone Use in the Treatment of ARDs
Villar et al (Lancet Respir Med. 2020;8:267-276) attempted to demonstrate the effect of steroids in patients with moderate to severe acute respiratory distress syndrome (ARDS) along with modern standard ICU practices, including lung-protective mechanical ventilation.
ARDS, Concise Critical Appraisal
Concise Critical Appraisal: Dexamethasone Use in the Treatment of COVID-19
This Concise Critical Appraisal offers a look into the results of the RECOVERY trial published in the New England Journal of Medicine, which demonstrated that dexamethasone improved mortality in hospitalized patients with COVID-19.
Concise Critical Appraisal, Coronavirus, COVID-19, Dexamethasone
Concise Critical Appraisal: Early Use of Tranexamic Acid in the Treatment of Gastrointestinal Bleeds
This Concise Critical Appraisal offers a deep dive into the HALT-IT trial, which investigated whether early use of tranexamic acid to treat acute severe gastrointestinal bleeds would reduce overall mortality while limiting the burden of thromboembolic events.
Concise Critical Appraisal, Nutrition
Concise Critical Appraisal: PERSEVERE Biomarkers in Predicting AKI in Pediatric Septic Shock
Can the biomarkers identified in the Pediatric Sepsis Biomarker Risk Model (PERSEVERE II) be used to predict acute kidney injury and renal recovery in pediatric septic shock? This Concise Critical Appraisal explores a study in which Stanski et al (Am J Respir Crit Care Med. 2020;201:848-855) sought to answer this question.
Concise Critical Appraisal, renal, sepsis, Septic Shock
Concise Critical Appraisal: Use of Early Versus Late Enteral Nutrition in Critically Ill Children
What is the benefit of early versus late nutrition in critically ill children? In this Concise Critical Appraisal, Daniel E. Sloniewsky, MD, FCCM, offers a deep dive on this Pediatric Critical Care Medicine article by Srinivasan et al, which sought to answer this question using data from the Heart and Lung Failure-Pediatric Insulin Titration (HALF-PINT) study.