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Tag: COVID-19

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Do you favor pressure or volume control ventilation in patients with acute respiratory distress syndrome from COVID-19?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on March 10, 2021


Does ketamine help resolve agitation or delirium? Are hallucinations a possible side effect of ketamine?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on March 10, 2021


For patients with severe acute respiratory distress syndrome from COVID-19, how do you prevent delirium when you cannot provide a sedation vacation or spontaneous breathing trial?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on March 10, 2021


When delirium prevention measures are ineffective for ICU patients with delirium, which therapies do you recommend trying next?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on March 10, 2021


Which environmental and medical therapies do you believe are most effective in preventing delirium in the ICU?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on March 10, 2021


Variation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic

From Critical Care Medicine. The authors characterize emergency responses across hospitals in the United States over time and in the context of local case rates early in the coronavirus disease 2019 pandemic.


Percutaneous Dilational Tracheostomy for Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation

From Critical Care Medicine. The authors assess the impact of percutaneous dilational tracheostomy in coronavirus disease 2019 patients requiring mechanical ventilation and the risk for healthcare providers.


Anticoagulation Therapy in Patients With Coronavirus Disease 2019: Results From a Multicenter International Prospective Registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019 [HOPE-COVID19])

From Critical Care Medicine. The authors evaluate the efficacy of anticoagulation in coronavirus disease 2019 hospitalized patients and its impact on survival.


A Comparison of Thrombosis and Hemorrhage Rates in Patients With Severe Respiratory Failure Due to Coronavirus Disease 2019 and Influenza Requiring Extracorporeal Membrane Oxygenation

From Critical Care Medicine. The authors describe and compare rates of venous thromboembolism and hemorrhage in patients with coronavirus disease 2019 against a historic population of patients with influenza pneumonia who required extracorporeal membrane oxygenation.


The Characterization of the Toll of Caring for Coronavirus Disease 2019 on ICU Nursing Staff

From Critical Care Explorations. In this brief report, the authors conclude there are indications that registered nurses providing care for coronavirus disease 2019 in the ICU reported increased thermal discomfort coinciding with elevated energy expenditure and a more pronounced self-perception of effort, stress, and mental demand.


The Initial Impact of the Coronavirus Disease 2019 Pandemic on ICU Family Engagement: Lessons Learned From a Collaborative of 27 ICUs

From Critical Care Explorations. While the collaborative model can help promote ICU family engagement initiatives, the authors found that coronavirus disease 2019 has impeded implementation of these initiatives even among motivated units.


In Vitro–Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019

From Critical Care Explorations. The authors evaluated the in vitro effects of dexamethasone phosphate on T cell function in peripheral blood mononuclear cells derived from patients with acute, severe, and moderate coronavirus disease 2019.


Editorial: Be Careful and Protect Yourself, It Is in the Air

From Critical Care Medicine. In this editorial, the authors discuss hospital staff safety in the article "Transmission of Severe Acute Respiratory Syndrome Coronavirus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 During Aerosol-Generating Procedures in Critical Care: A Systematic Review and Meta-Analysis of Observational Studies" by Chan et al.


Letter to the Editor: Unclear Benefit of Early Tracheostomy In Patients With Coronavirus Disease 2019

From Critical Care Medicine. This online letter to the editor was written in response to Early Percutaneous Tracheostomy In Coronavirus Disease 2019: Association With Hospital Mortality and Factors Associated With Removal of Tracheostomy Tube at ICU Discharge. A Cohort Study on 121 Patients" by Rosano et al.


Letter to the Editor: Questioning the Futility of Cardiopulmonary Resuscitation in Patients With Severe Coronavirus Disease 2019

From Critical Care Medicine. This online letter to the editor was written in response to " Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest?" by Shah et al.


Letter to the Editor: Cardiopulmonary Resuscitation in Coronavirus Disease 2019: Far from Futile

From Critical Care Medicine. This online letter to the editor was written in response to " Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest?" by Shah et al.


Early Tocilizumab Dosing Is Associated With Improved Survival in Critically Ill Patients Infected With Severe Acute Respiratory Syndrome Coronavirus-2

From Critical Care Explorations. The authors identify the most efficacious timing for tocilizumab administration in critically ill patients infected with severe acute respiratory syndrome coronavirus-2.


Characteristics of Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Comparison With Influenza in Children Admitted to U.K. PICUs

From Critical Care Explorations. The authors describe the nationwide U.K. PICU experience of severe acute respiratory syndrome coronavirus-2 infection during the first wave of the pandemic and compare this with the critical care course of the 2019 influenza cohort.


Mechanical Ventilation and Coronavirus Disease 2019: A Case-Control Analysis of Clinical Characteristics, Lung Mechanics, and Mortality

From Critical Care Explorations. The authors investigated the differences in clinical course, ventilator mechanics, and outcomes of patients with coronavirus disease 2019 secondary to acute respiratory distress syndrome infection compared with a historical cohort of acute respiratory distress syndrome.


Letter to the Editor: Comparing Seasonal Trends in Coronavirus Disease 2019 Patient Data at a Quaternary Hospital in New York City

From Critical Care Explorations. In this Letter to the Editor, the authors report initial patient characteristics and outcomes from a large quaternary referral center in New York City between Spring, Summer, and Winter, including prevalence of renal failure, respiratory failure, and mortality; stratified across several key populations of interest including all patients, ICU patients, those requiring of noninvasive positive pressure ventilation and high-flow nasal cannula, and those intubated in each time period.


Association Between Treatments and Short-Term Biochemical Improvements and Clinical Outcomes in Postsevere Acute Respiratory Syndrome Coronavirus-2 Inflammatory Syndrome

From Pediatric Critical Care Medicine. The authors analyzed the short-term biochemical improvements and clinical outcomes following treatment of children with postsevere acute respiratory syndrome coronavirus-2 inflammatory syndrome (multisystem inflammatory syndrome in children/pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus-2) admitted to U.K. PICUs and collated current treatment guidance from U.K. PICUs.


Johnson & Johnson’s Janssen COVID-19 Vaccine: What Clinicians Need to Know

In the past few weeks more than 7 million doses of Johnson & Johnson’s Janssen COVID-19 vaccine have been administered to people in the United States. In clinical trials of approximately 40,000 people, the J&J vaccine given as a single shot was 66% effective at preventing the illness due to the SARS-CoV-2 virus known as COVID-19. Because the J&J vaccine is a single shot, it has been preferred in some circumstances.


Concise Critical Appraisal: Surviving Sepsis Campaign COVID-19 Guidelines Update

The updated Surviving Sepsis Campaign (SSC) COVID-19 guidelines are now available, reflecting the learnings from the latest major studies. This month’s Concise Critical Appraisal dives into the update to outline the changes and new recommendations made by the international panel and discusses limitations of the available data.


Maternal Mortality During the COVID-19 Pandemic

This resource details maternal mortality during the COVID-19 pandemic.

This is SCCM curated COVID-19 microlearning content.


COVID-19 and Pregnancy, Management Considerations

This resource details COVID-19 and pregnancy management.

This is SCCM curated COVID-19 microlearning content.


Awake Self-Proning in COVID-19 ARDS

This resource details methods for awake self-proning for COVID-19 patients with ARDS. This is SCCM curated COVID-19 microlearning content.


Infection Control from the ED to the ICU: Triage to Transport

The care of patients with COVID-19 requires careful steps for preventing infection of staff and other patients throughout the continuum care from the emergency department to the ICU. This webinar consisted of an expert panel discussion of questions and case studies that addressed burning questions. Participants also received an infographic with pearls from the panel experts to help in their practice. Webcast Recorded on Friday, March 26, 2021


Infographic: Infection Control from the Emergency Department to the ICU

This infographic resource details best practices to mitigate infection control from the ED to the ICU.

This is SCCM curated COVID-19 microlearning content.


Online Letter to the Editor: Is “Mega-Dose” IV Vitamin C Required for Septic and Critical Coronavirus Disease 2019 Patients?

From Critical Care Medicine. This online letter to the editor was written in response to “Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C” by Lankadeva et al


Online Letter to the Editor: Resuscitation and Coronavirus Disease 2019: A Reappraisal

From Critical Care Medicine. This online letter to the editor was written in response to the article “Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest? By Shah et al.


Online Letter to the Editor: Judging Futility of Resuscitation Attempts for Coronavirus Disease 2019 Patients Requires Better Time Data

From Critical Care Medicine. This online letter to the editor was written in response to the article “Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest? By Shah et al.


Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019: Cohort Study From a New York City Critical Care Recovery Clinic

From Critical Care Medicine. In this article, authors found that survivors of critical illness related to coronavirus disease 2019 are at high risk of developing postintensive care syndrome.


Online Letter to the Editor: Is Mortality Rate of Ventilated Patients With Coronavirus Disease 2019 So High?

From Critical Care Medicine.  This is an online Letter to the Editor in response to “De Novo Renal Failure and Clinical Outcomes of Patients With Critical Coronavirus Disease 2019” by Forest et al.


Online Letter to the Editor: Potential Endotype Transition for Coronavirus Disease 2019–Related Sepsis With Longitudinal Transcriptome Profiling

From Critical Care Medicine. This an online Letter to the Editor in response to the article by Sweeney et al. “Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus disease 2019."


Online Letter to the Editor: Plasmapheresis Efficiency in Coronavirus Disease 2019: More Related to What You Add and Not What You Take Away?

From Critical Care Medicine. This is an online Letter to the Editor in response to the article by Fernandez et al. “Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 Infection.”


Thromboelastography Parameters and Platelet Count on Admission to the ICU and the Development of Venous Thromboembolism in Patients With Coronavirus Disease-2019

From Critical Care Explorations. The authors’ data, discussed in this article, did not support the use of thromboelastography to risk stratify critically ill adults with coronavirus disease 2019 for the development of venous thromboembolism or to guide decisions about anticoagulation.


Changes in Stress and Workplace Shortages Reported by U.S. Critical Care Physicians Treating Coronavirus Disease 2019 Patients

From Critical Care Medicine. In this study, the authors found that stress, staffing, and, to a lesser degree, personal protective equipment shortages faced by U.S. critical care physicians remain high, with stress levels higher among women.


A Systematic Review of the Incidence and Outcomes of In-Hospital Cardiac Arrests in Patients With Coronavirus Disease 2019

From Critical Care Medicine. The authors investigated the incidence, characteristics, and outcomes of in-hospital cardiac arrest in patients with coronavirus disease 2019 and describe the characteristics and outcomes for patients with in-hospital cardiac arrest within the ICU, compared with non-ICU patients with in-hospital cardiac arrest.


Severe Acute Respiratory Syndrome–Associated Coronavirus 2 Infection and Organ Dysfunction in the

From Critical Care Explorations. In this review article, the authors summarize the current state of research in coronavirus disease 2019 pathophysiology within the context of potential organ-based disease mechanisms and opportunities for translational research.


Rapid Development of a Tool for Prioritizing Patients with Coronavirus Disease 2019 for Intensive Care

From Critical Care Explorations. In this study, the authors share a new approach for rapidly developing a decision-support tool for prioritizing patients with coronavirus 2019 disease for admission to ICUs.


ICU Bed Utilization During the Coronavirus Disease 2019 Pandemic in a Multistate Analysis—March to June 2020

From Critical Care Explorations. The authors examined ICU census trends in relation to ICU bed capacity during the rapid increase in severe coronavirus disease 2019 cases early during the pandemic, and concluded they concluded tha ttheir findings demonstrate the short-term adaptability of U.S. healthcare institutions in redirecting limited resources to accommodate a public health emergency.


Detection and Profiling of Human Coronavirus Immunoglobulins in Critically Ill Coronavirus Disease 2019 Patients

From Critical Care Explorations. The authors performed anticoronavirus immunoglobulin G profiling of critically ill coronavirus disease 2019 patients to better define their underlying humoral response.


ABCDEF Bundle and Supportive ICU Practices for Patients With Coronavirus Disease 2019 Infection: An International Point Prevalence Study

From Critical Care Explorations. This point prevalence study showed low implementation of the ABCDEF bundle for patients with COVID-19.


Physiologic Improvement in Respiratory Acidosis Using Extracorporeal Co2 Removal With Hemolung Respiratory Assist System in the Management of Severe Respiratory Failure From Coronavirus Disease 2019

From Critical Care Explorations. In this retrospective case series of 29 patients, the authors demonstrated efficacy of extracorporeal Co2 removal using the Hemolung Respiratory Assist System to improve respiratory acidosis in patients with severe hypercapnic respiratory failure due to coronavirus disease 2019.


Collaboration Between Tele-ICU Programs Has the Potential to Rapidly Increase the Availability of Critical Care Physicians—Our Experience Was During Coronavirus Disease 2019 Nomenclature

From Critical Care Explorations.  The authors describe implementing a connected network between two tele-ICU programs to support staffing and rounding during the first wave of the coronavirus disease 2019 pandemic in the United States.


Standard Sedation and Sedation With Isoflurane in Mechanically Ventilated Patients With Coronavirus Disease 2019

From Critical Care Explorations. The authors describe sedative and analgesic drug utilization in a cohort of critically ill patients with coronavirus disease 2019 and compare standard sedation with an alternative approach using inhaled isoflurane.


Virtual Communication Embedded Bedside ICU Rounds: A Hybrid Rounds Practice Adapted to the Coronavirus Pandemic

From Pediatric Critical Care Medicine. In this article, the authors found that hybrid rounds employed during pandemic facilitated social distancing while retaining patient-centered multidisciplinary ICU rounds but compromised teaching during rounds.


Online Letter to the Editor: Early Percutaneous Tracheostomy in the Coronavirus Disease 2019 Era: Shining New Light on Old Questions

From Critical Care Medicine. In this Online Letter to the Editor, the authors comment on an article by Rosano et al. in which it was demonstrated that early tracheostomy can be performed with acceptable safety in the midst of a pandemic and note that the study raises important questions related to the downsides of routinely performing tracheostomy, tailoring timing of tracheostomy and optimal protocols for decannulation.


Live Tweeting the Discovery of a New Coronavirus Disease 2019–Related Syndrome in Children

From Pediatric Critical Care Medicine. The authors of this Editorial sought to assess the evolving discussion surrounding the naming of a novel pediatric hyperinflammatory syndrome – a condition that showed overlapping features of Kawasaki disease and toxic shock syndrome -- through the analysis of its evolution around the Twitter hashtag #PedsICU.


First and Second Waves of Coronavirus Disease 2019 in Madrid, Spain: Clinical Characteristics and Hematological Risk Factors Associated With Critical/Fatal Illness

From Critical Care Explorations  In this study, the authors sought to determine similarities and differences in clinical characteristics between the patients from two waves of severe acute respiratory syndrome coronavirus-2 infection at the time of hospital admission, as well as to identify risk biomarkers of coronavirus disease 2019 severity.


Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019–Related Respiratory Failure

From Critical Care Medicine In this study, the authors found that in-hospital mortality was lower in mechanically ventilated hypoxemic patients with coronavirus disease 2019 treated with early proning compared with patients whose treatment did not include early proning.


When should extracorporeal membrane oxygenation be initiated?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


What are some resources for non-ICU clinicians who are interested in learning more about critical illness related to COVID-19?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


What is the most appropriate ventilation mode for patients with COVID-19 and how long should patients be on that ventilation mode?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


What is the role of ivermectin in the treatment of COVID-19?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


Which populations should be anticoagulated? What is the procedure for anticoagulation and how long should it take?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021
 


What is the most appropriate treatment for patients (both inpatients and outpatients) who have a positive polymerase chain reaction test but no symptoms?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


When are steroids indicated for COVID-19? What is the appropriate dosage and duration?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


What is the current role of tocilizumab?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


Can children be anticoagulated or only adults?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


Can antiplatelets be administered at the same time as anticoagulation in patients with COVID-19?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


Do you have any comments about patients on  clopidogrel who had COVID-19 and developed ischemic stroke secondary to embolic thrombosis?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


Which patients should be proned and for how long?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


What are the recommendations for protection of healthcare professionals who perform aerosolized procedures?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


In a patient who has COVID-19 respiratory infection and requires intubation, when should the patient be intubated and what is the intubation process?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


How should patients be weaned off mechanical ventilation? When should they be weaned and how long should weaning take?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021


What is your recommendation on use of neuromuscular blockade?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021.


The Role of Aspirin for the Treatment of SARS-CoV-2

This resource details the role of aspirin when treating COVID-19 patients.


Pressure Injury Prevention and Management in COVID-19 patients

This resource details pressure injuries seen with COVID-19 patients.


Transmission of Severe Acute Respiratory Syndrome Coronavirus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 During Aerosol-Generating Procedures in Critical Care: A Systematic Review and Meta-Analysis of Observational Studies

From Critical Care Medicine. In this study, the authors found that personal protective equipment reduce the odds of contracting severe acute respiratory syndrome coronavirus 1 and severe acute respiratory syndrome coronavirus 2.


Efficacy of Serum Angiotensin II Levels in Prognosis of Patients With Coronavirus Disease 2019

From Critical Care Medicine. In this study, the authors found that serum angiotensin II levels decrease significantly in patients with coronavirus disease 2019, and this decrease is correlated with lung damage.


Cardiovascular Disease and Severe Hypoxemia Are Associated With Higher Rates of Noninvasive Respiratory Support Failure in Coronavirus Disease 2019 Pneumonia

From Critical Care Explorations. The authors describe outcomes with high-flow oxygen delivered through nasal cannula and noninvasive positive pressure ventilation in coronavirus disease 2019 acute hypoxemic respiratory failure and identify individual factors associated with noninvasive respiratory support failure.


Editorial: The Complex Issue of Race and Coronavirus Disease 2019 in the ICU

From Critical Care Medicine. In this editorial, the authors discuss the article Racial Differences in a Detroit, MI, ICU Population of Coronavirus Disease 2019 Patients by Lazar et al. about healthcare inequalities and  disparate outcomes.


The Lived Experience of ICU Clinicians During the Coronavirus Disease 2019 Outbreak: A Qualitative Study

From Critical Care Medicine. In this qualitative study, the authors found that, among ICU clinicians, there was a sense of total professional engagement during the surge. Caring for critically ill coronavirus disease 2019 patients was fraught with challenges, and that the experience generated strong feelings of responsibility, as clinicians felt they had to compensate for the absence of family members.


D-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Medicine.  In a large multicenter cohort study of critically ill patients with coronavirus disease 2019, the authors found higher D-dimer levels were independently associated with a greater risk of death.


von Willebrand Factor Multimer Formation Contributes to Immunothrombosis in Coronavirus Disease 2019

From Critical Care Medicine.  The authors believe that the findings of this study provide a rationale to consider plasma exchange as a therapeutic option in COVID-19 and to include von Willebrand factor and ADAMTS13 in the diagnostic workup.


Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness

From Critical Care Medicine.  In this article, the authors identify research priorities that represent a roadmap for investigation in COVID-19. 


CDC Resources: Well-Being

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Well-Being 


SCCM’s 50th Critical Care Congress: COVID-19: Global Voices and Perspectives

From SCCM's 50th Critical Care Congress. Critical care professionals from around the world shared their thoughts and perspectives on COVID-19.


SCCM’s 50th Critical Care Congress: Frontline Nursing: Leadership Lessons From the Battlefield to the COVID-19 Crisis

From SCCM's 50th Critical Care Congress. Elizabeth J. Bridges, CCNS, MSN, PhD, RN, highlights lessons learned in frontline nursing during the COVID-19 pandemic and what they mean for the future of leadership.


SCCM’s 50th Critical Care Congress: Public Health Crises: From Measles to COVID-19

From SCCM's 50th Critical Care Congress. New York State Health Commissioner Howard A. Zucker, MD, JD, FCCM, discuss public health directives and policies that have proven effective at managing dangerous spikes in hospitalizations during New York State’s response to recent measles and COVID-19 outbreaks.


SCCM’s 50th Critical Care Congress: Surviving Sepsis Campaign COVID-19 Guidelines Therapeutics Update

From SCCM's 50th Critical Care Congress. Learn more about the guidelines therapeutics update and the methodology and its application to public health emergencies.


A Case-Control Study of Prone Positioning in Awake and Nonintubated Hospitalized Coronavirus Disease 2019 Patients

From Critical Care Explorations. In this study, the authors found no significant association with reduced risk of invasive mechanical ventilation or inhospital mortality after adjusting for baseline severity of illness and oxygenation status.


IDSA Resources: Pharmacology

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Infectious Diseases Society of America (IDSA) COVID-19 Real-Time Learning Network. These resources are categorized as Pharmacology


CDC Resources: Pharmacology

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Pharmacology


ACEP COVID-19 Resource: Hurting and Helping: Team Care and Self Care During Crisis

ACEP is collaborating with the American Association of Emergency Psychiatry on some new resources related to physician wellness and mental health during COVID-19. 


IDSA Resources: Administration

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Infectious Diseases Society of America (IDSA) COVID-19 Real-Time Learning Network. These resources are categorized as Administration


IDSA Resources: Pulmonary

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Infectious Diseases Society of America (IDSA) COVID-19 Real-Time Learning Network. These resources are categorized as Pulmonary


CDC Resources: Obstetrics

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Obstetrics


IDSA Resources: Infection

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Infectious Diseases Society of America (IDSA) COVID-19 Real-Time Learning Network. These resources are categorized as Infection


CDC Resources: Pediatrics

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Pediatrics


Process Adaptations for Airway Management in COVID patients

This is an infographic that details process adaptations for airwary management. This is a community developed COVID-19 microlearning resource.


Lung Ultrasound and Sonographic Subpleural Consolidation in COVID-19 Pneumonia Correlate with Disease Severity

This is an article that details lung ultrasound and sonographic subpleural consolidation in COVID-19 pneumonia correlated with disease serverity. This is a community developed COVID-19 microlearning resource.


Editorial: The Pandemic Paradox: A Celebrated Exhaustion

From Critical Care Medicine. In this editorial, the author discussed burnout and its impact on clinicians.


Coronavirus Disease 2019 Immediately Increases Burnout Symptoms in ICU Professionals

Fron Critical Care Medicine. This study shows that overburdening of ICU professionals during an extended period of time leads to symptoms of burnout. 


Severe Acute Respiratory Syndrome Coronavirus-2 Infections in Critical Care Staff: Beware the Risks Beyond the Bedside

From Critical Care Medicine. In this study, the authors found that staff who developed coronavirus disease 2019 were less likely to have caught it from their patients in critical care. Other staff, other areas of the hospital, and the wider community are more likely sources of infection.


Outcomes of Patients With COVID-19 Receiving Organ Support Therapies: The International VIRUS Registry

From Critical Care Medicine. The authors describe the outcomes of hospitalized patients in a multicenter, international coronavirus disease 2019 registry.


ACEP COVID-19 Resource: COVID-19 Field Guide

This is a link to an ACEP COVID-19 external resource entitled, "The American College of Emergency Physicians Guide to Coronavirus Disease (COVID-19)."


Long Term Neurological Complications of COVID-19​

This resource details the long term neurolgical complication seen in COVID-19 patients.

This is SCCM curated COVID-19 microlearning content.


Is there a Role for Angiotensin II in COVID-19 Patients with Shock?​

This resource details how angiotensin II can used for COVID-19 patients with shock.

This is SCCM curated COVID-19 microlearning content.


Clinical Pearls on Sedative Weaning

This resource details tips for sedative weaning for COVID-19 patients.

This is SCCM curated COVID-19 microlearning content.


Post-Hospital Treatment of Pain

This resource details the post-hospital treament of pain.

This is SCCM curated COVID-19 microlearning content.


Critical Ethics: How to Balance Patient Autonomy With Fairness When Patients Refuse Coronavirus Disease 2019 Testing

From Critical Care Explorations. In this review articles, the authors set out to identify the most ethical way a given healthcare system may respond to a patient’s refusal to undergo coronavirus disease 2019 testing.


Dysphagia in Patients With Severe Coronavirus Disease 2019—Potential Neurologic Etiologies

From Critical Care Explorations. In this case series, the authors investigate dysphagia in patients with severe coronavirus disease 2019.


Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia

From Critical Care Explorations. In this study, the authors assessed the effect of early invasive mechanical ventilation in coronavirus disease-2019 with acute hypoxemic respiratory failure on day-60 mortality.


The Association of Preinfection Daily Oral Anticoagulation Use and All-Cause in Hospital Mortality From Novel Coronavirus 2019 at 21 Days: A Retrospective Cohort Study

From Critical Care Explorations. In this retrospective study, the authors sought to understand the association of preinfection daily oral anticoagulation use and the short-term mortality of patients hospitalized with coronavirus disease 2019.


An 18-Year-Old Survivor With a Body Mass Index of 73.9 kg/m2 on Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019: A Collaborative Multidisciplinary Effort

From Critical Care Explorations. In this case report, the authors describe a case of acute respiratory distress syndrome secondary to coronavirus disease 2019 infection in setting of super morbid obesity (body mass index 73.9 kg/m2) with the successful use of extracorporeal membrane oxygenation.


Presence of Spontaneous Echo Contrast on Point-of-Care Vascular Ultrasound and the Development of Major Clotting Events in Coronavirus Disease 2019 Patients

From Critical Care Explorations. In this study, the authors assessed for the prevalence and consequences of spontaneous echo contrast on point-of-care vascular ultrasound in coronavirus disease 2019.


Evaluation of Hypertriglyceridemia in Critically Ill Patients With Coronavirus Disease 2019 Receiving Propofol

From Critical Care Explorations. In this study, the authors report the prevalence of, and evaluate risk factors for, the development of hypertriglyceridemia (defined as a serum triglyceride level of > 400 mg/dL) in patients with coronavirus disease 2019 who received propofol.


Correlation of Respiratory Physiologic Parameters in Mechanically Ventilated Coronavirus Disease 2019 Patients

From Critical Care Explorations. In this article, the authors report simultaneously measured respiratory parameters (static lung compliance, alveolar dead space ventilation, and shunt fraction) in 14 patients with advanced coronavirus disease 2019-related acute respiratory distress syndrome.


The Effects of ICU Crisis Reorganization on Outcomes in Patients Not Infected With Coronavirus Disease 2019 During the Initial Surge of the Coronavirus Disease 2019 Pandemic

From Critical Care Explorations. In this study, the authors determined if ICU reorganization due to the coronavirus disease 2019 pandemic affected outcomes in critically ill patients who were not infected with coronavirus disease 2019.


Severe Acute Respiratory Syndrome Coronavirus-2-Associated Acute Kidney Injury: A Narrative Review Focused Upon Pathophysiology

From Critical Care Medicine. In this article, the authors conclude that a personalized approach to each patient with acute kidney injury based on the timing and severity of disease is necessary in order to provide appropriate treatment.


Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning

From Critical Care Medicine. In this study, the authors looked for the true prevalence of thrombotic complications in critically ill patients with severe coronavirus disease 2019 on the ICU, with or without extracorporeal membrane oxygenation.


Capillary Leukocytes, Microaggregates, and the Response to Hypoxemia in the Microcirculation of Coronavirus Disease 2019 Patients

From Critical Care Medicine. In this study, the authors hypothesized that coronavirus disease 2019 patients exhibit sublingual microcirculatory alterations caused by inflammation, coagulopathy, and hypoxemia.


Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery

From Critical Care Medicine. The authors sought to establish the core outcome measures for respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality for trials in coronavirus disease 2019.


The primary cause of gas exchange impairment in COVID-19 is thought to be different from regular acute respiratory distress syndrome (ARDS). There has been controversy regarding inhaled nitric oxide.

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021


How do you decide whether there might be a superimposed bacterial pneumonia? What is your antibiotic of choice for treating this pneumonia?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Is there any consensus about prophylactic anticoagulation in patients without known venous thromboembolism?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Are there any data supporting convalescent plasma?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


If you discharge a patient home when the patient still requires oxygen, would you have the patient complete the 10 days of dexamethasone or stop at discharge, since the data are for hospitalized patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Are you giving all patients dexamethasone? What steroid regimen have you found most helpful? What dosing do you recommend for obese patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Because of the need for such high doses of sedatives and narcotics, how are you preventing post-intensive care syndrome and delirium?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Once a patient is intubated and on mechanical ventilation, how do you keep the patient sedated appropriately without reaching extremely high doses of sedatives and narcotics?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Are you using more advanced ventilation modes, such as airway pressure ventilation (APRV) or oscillator?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Once you intubate a patient for COVID-19, what is your starting ventilation strategy?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


How often do you prone nonintubated patients? Are most patients on high-flow or noninvasive support being proned? What schedule is being used to alternate between prone and supine positions? Does the same schedule apply to intubated patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


In permissive hypoxemia and acute respiratory distress syndrome, the literature typically talks about a partial pressure of oxygen of 60 mm Hg. How low should this pressure get for intubated patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Is there any difference in outcome between patients who are intubated earlier from mechanical ventilation compared with those who are intubated later?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Do you have a preference between CPAP and BiPAP? Does it depend on the etiology of the respiratory failure? What is your experience with current patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


For patients being treated for COVID-19, do you switch back and forth between high-flow nasal cannula and noninvasive ventilation?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on January 13, 2021.


Preventing Skin Injuries from Long-Term Prone Positioning

This resource detail how to prevent skin injuries due to long-term proning. This is SCCM curated COVID-19 microlearning content.


Antibiotic Stewardship Crisis during COVID-19

This resource covers antimicrobial stewardship concerns during the COVID-19 pandemic. This is SCCM curated COVID-19 microlearning content.


Point-of-Care Ultrasound for COVID-19 Pneumonia Patients in the ICU

This is an article that details point of care ultrasound for COVID-19 pneumonia. This is a community developed COVID-19 microlearning resource.


Infographic: Multi-organ Point-of-care Ultrasound for COVID-19 (PoCUS4COVID): International Expert Consensus

This is an infographic that details multi-organ point of care ultrasound during the COVID-19 pandemic. This is a community developed COVID-19 microlearning resource.


Multi-organ Point-of-care Ultrasound for COVID-19 (PoCUS4COVID): International Expert Consensus

This is an article that details multi-organ point of care ultrasound during the COVID-19 pandemic. This is a community developed COVID-19 microlearning resource.


Nursing Staffing Models: Telemetry Contingency & Crisis Model

This is a nursing staffing model for telemetry contigencies. This is a community developed COVID-19 microlearning resource.


Nursing Staffing Models: DSU (Stepdown) Contingency Staffing Model

This is a nursing staffing model DSU (Stepdown) contingencies. This is a community developed COVID-19 microlearning resource.


Nursing Staffing Models: Med-Surg Contingency & Crisis Model

This is a nursing staffing model for Med-Surg emergency contingencies and crises. This is a community developed COVID-19 microlearning resource.


Nursing Staffing Models: ICU Staffing Plan: Contingency & Crisis Model

This is a nursing staffing model for the ICU. This is a community developed COVID-19 microlearning resource.


Nursing Staffing Models: Emergency Contingency Staffing

This is a nursing staffing model for emergency contingencies. This is a community developed COVID-19 microlearning resource.


CDC Resources: Infection

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Infection   


IDSA Resources: Obstetrics

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Infectious Diseases Society of America (IDSA) COVID-19 Real-Time Learning Network. These resources are categorized as Obstetrics


COVID-19 Vaccine Storage Considerations

The original webcast served as a COVID-19 vaccination primer that can be used by all types of healthcare workers (HCWs) to help them prepare for Operation Warp Speed and the mass vaccination efforts in the United States. This section of the webcast focused on an vaccine storage considerations. Webcast Recorded on Friday, January 8, 2021


IDSA Resources: Well-Being

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Infectious Diseases Society of America (IDSA) COVID-19 Real-Time Learning Network. These resources are categorized as Well-Being


Discovery VIRUS Registry Outcomes and STOP-VIRUS ICU Learning Collaborative

The first outcomes of VIRUS were recently published in Critical Care Medicine. More than 20 manuscripts are being prepared for publication during the next several months. Additionally, sites have been invited to submit ancillary study ideas drawing on registry data. Of the 150 proposed, more than 60 have been approved.
 
Join the registry today and contribute to this important data collection.


Tocilizumab May Reduce Mortality in Certain COVID-19 Patients

Two recent trials suggest that immune-damping drugs such as tocilizumab may reduce mortality in patients with severe COVID-19.


Readiness for and Response to Coronavirus Disease 2019 Among Pediatric Healthcare Providers: The Role of Simulation for Pandemics and Other Disasters

From Pediatric Critical Care Medicine

Early preparation for the training and education of healthcare providers, as well as the continuation or modification of routine medical education programs, is of great importance in times of the coronavirus disease 2019 pandemic or other public health emergencies; this study aimed to characterize these self-reported efforts by the pediatric simulation community.


Portable Magnetic Resonance Imaging for ICU Patients

From Critical Care Explorations  

In this case series of patients, the authors found use of portable MRI to be safe, feasible, and led to changes in clinical management based on imaging results.


Integral Use of Thromboelastography With Platelet Mapping to Guide Appropriate Treatment, Avoid Complications, and Improve Survival of Patients With Coronavirus Disease 2019–Related Coagulopathy

From Critical Care Explorations

In this study, the authors round that thromboelastography with platelet mapping better characterizes the spectrum of coronavirus disease 2019 coagulation-related abnormalities and may guide more tailored, patient-specific therapies in thostudyse infected with coronavirus disease 2019.


Racial Differences in a Detroit, MI, ICU Population of Coronavirus Disease 2019 Patients

From Critical Care Medicine  

Contrary to previously held beliefs surrounding the coronavirus 19 pandemic, this study found that, in critically ill patients infected with coronavirus disease 2019, people of color had a lower 28-day mortality than Whites with no difference in hospital mortality, ICU length of stay, or rates of intubation. 


CDC Resources: Research

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Research


CDC Resources: Administration

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Administration


Federal Healthcare Resilience Working Group (HRWG): Surge Roadmap Slides

The Federal Healthcare Resilience Working Group (HRWG) created Strategies for Managing a Surge in COVID-19 Cases, also referred to as the Surge Roadmap, to provide guidance to the state, tribal, local, and territorial (STLT) jurisdictions on how to enhance their healthcare capabilities in response to a surge in COVID-19 cases.


CDC Resources: Immunology

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Immunology


Do you have any experience with tocilizumab and related drugs? What is your impression of them?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


Evidence-based COVID-19 ICU Management Guide v2

This resource is a guide for evidence-based COVID-19 ICU management. This management guide was not intended to be a therapeutic guide, therefore information on any specific COVID-19 treatments have not been covered. British Columbia has a therapeutics committee in coordination with BCCDC which publish separate, regularly updated guidelines on this subject. This guide is currently available for reference by staff working in Vancouver Coastal Health in all areas managing COVID-19 patients. This is a community developed COVID-19 microlearning resource.


Early Respiratory Outcomes Following Cardiac Surgery in Patients With COVID‐19

This resource details early respiratory outcomes following cardiac surgery in patients with COVID‐19. This is a community developed COVID-19 microlearning resource.


Cytokine Storm and ARDS - Comparison of Corticosteroid Dosing Strategies

This resource details how to manage cytokine storm and ARDS by comparing corticosteriod dosing strategies for COVID-19 patients. This is SCCM curated COVID-19 microlearning content.


What advice do you have regarding core skills for the medical surgical nurse, general hospital pharmacist, hospitalist, or emergency physician without dedicated critical care training who will be joining your team to help care for these patients, perhaps

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


When you are called to accept a patient in an ECMO center, what are your considerations for transfer? What information would you like to know from the referring team and what interventions should be performed?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


How do we prevent VTEs and how do we survey for them? Should patients receive standard prophylaxis? Should all ventilated patients receive full-dose anticoagulation? What are your practices and how have you approached this at your center?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


What is your local practice for using Remdesivir in the ICU?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


Is the standard 6 milligrams of dexamethasone for up to 10 days the only option? Do all patients need this or is there any evidence for trying something different? Has there been any experience with using a higher dexamethasone dose?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


What medication adjuncts can clinicians use for the patient with severe hypoxemia who is receiving 100% oxygen but only getting an oxygen reading of 90%? What are some strategies clinicians can use to reduce some of these difficulties?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


For patients who fail to adequately oxygenate with less invasive methods, what are your triggers for starting mechanical ventilation? What would you want the non-ICU clinician to know before going down that path? When do you decide to intubate someone?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


What is a general go-to ventilator setting? Once you have intubated the patient, how would you recommend that the clinician set up the ventilator for a hypoxemic patient with evolving ARDS?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on December 9, 2020.


Coronavirus Disease 2019 Calls for Predictive Analytics Monitoring—A New Kind of Illness Scoring System

From Critical Care Explorations

The authors believe that current illness severity scoring systems, which usually update only when clinicians measure vital signs or laboratory values, are poorly suited for early detection of this kind of rapid clinical deterioration, and therefore propose that continuous predictive analytics monitoring, a new approach to bedside management, is more useful.


Thromboembolism, Hypercoagulopathy, and Antiphospholipid Antibodies in Critically Ill Coronavirus Disease 2019 Patients: A Before and After Study of Enhanced Anticoagulation

From Critical Care Explorations

In this study, the authors sought to determine the prevalence of thrombotic events, functional coagulation tests, inflammatory biomarkers, and antiphospholipid antibodies before and after enhanced anticoagulation in critically ill coronavirus disease 2019 patients.


Effects of Inhaled Epoprostenol and Prone Positioning in Intubated Coronavirus Disease 2019 Patients With Refractory Hypoxemia

From Critical Care Explorations

In this study, the authors found that, in critically ill, mechanically ventilated patients with coronavirus disease 2019 who had refractory hypoxemia, oxygenation improved to a greater extent with combined use of inhaled epoprostenol and prone positioning than with each treatment individually.


Propofol-Associated Hypertriglyceridemia in Coronavirus Disease 2019 Versus Noncoronavirus Disease 2019 Acute Respiratory Distress Syndrome

From Critical Care Explorations

In this study, the authors found that patients with coronavirus disease 2019 acute respiratory distress syndrome experienced a higher rate of propofol-associated hypertriglyceridemia than noncoronavirus disease 2019 acute respiratory distress syndrome patients, even after accounting for differences in propofol administration.


An Algorithm for Classifying Patients Most Likely to Develop Severe Coronavirus Disease 2019 Illness

From Critical Care Explorations

The authors developed an algorithm to assess whether someone is at high risk of admission to the ICU or dying from coronavirus disease 2019, should he or she test positive for coronavirus disease 2019.


Clinical Outcomes With the Use of Prophylactic Versus Therapeutic Anticoagulation in Coronavirus Disease 2019

From Critical Care Explorations

In this study, the authors found an increase in inhospital mortality was observed among patients on preemptive therapeutic anticoagulation.


Letter to the Editor: Breaking Silos: The Team-Based Approach to Coronavirus Disease 2019 Pandemic Staffing

From Critical Care Explorations

The authors describe experiences and lessons learned at NewYork-Presbyterian (NYP), one of the largest healthcare delivery systems in the United States, in creating an intercampus leadership teams to combat COVID-19.


Risk Factors for Invasive Pulmonary Aspergillosis in Critically Ill Patients With Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome

From Critical Care Explorations

The authors retrospectively evaluated cases of coronavirus disease 2019 acute respiratory distress syndrome patients and identified six patients that met the diagnosis of invasive pulmonary aspergillosis according to previously established definitions. 


Harmonizing Heterogeneous Endpoints in Coronavirus Disease 2019 Trials Without Loss of Information

From Critical Care Medicine

The authors aim to provide hands-on statistical guidelines for harmonizing heterogeneous endpoints in coronavirus disease 2019 clinical trials.


Inflammatory Response and Phenotyping in Severe Acute Respiratory Infection From the Middle East Respiratory Syndrome Coronavirus and Other Etiologies

From Critical Care Medicine

The authors evaluated the inflammatory response in patients with severe acute respiratory infection due to the Middle East respiratory syndrome and non-Middle East respiratory syndrome and assessed the presence of distinct inflammatory subphenotypes using latent class analysis.


Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation

From Critical Care Explorations

The authors present a case series of eleven patients, five treated with camostat mesylate and six treated with hydroxychloroquine.


A Propensity-Matched Cohort Study of Tocilizumab in Patients With Coronavirus Disease 2019

From Critical Care Explorations

The authors assessed the impact of tocilizumab therapy and found that it was associated with significantly improved survival in coronavirus disease 2019 patients.


Intravenous Immunoglobulin Plus Methylprednisolone Mitigate Respiratory Morbidity in Coronavirus Disease 2019

From Critical Care Explorations

The authors piloted a randomized trial of IV immunoglobulin in coronavirus disease 2019 patients and found significantly improved hypoxia and reduced hospital length of stay.


Rescue Treatment With High-Dose Gaseous Nitric Oxide in Spontaneously Breathing Patients With Severe Coronavirus Disease 2019

From Critical Care Explorations

The authors present a case series of patients who received nitric oxide inhalation as a rescue therapy for coronavirus disease 2019.


Timing of Tracheostomy for Prolonged Respiratory Wean in Critically Ill Coronavirus Disease 2019 Patients: A Machine Learning Approach

From Critical Care Explorations

The authors found that the optimal window for consideration of tracheostomy for ventilatory weaning in coronavirus disease 2019 patients is between day 13 and 17.


Frequency and Analysis of Unplanned Extubation in Coronavirus Disease 2019 Patients

From Critical Care Explorations

The authors found that coronavirus disease 2019 patients have a higher incidence of unplanned extubation that requires reintubation than noncoronavirus disease 2019 patients.


Online Letter to the Editor: Analysis of Critical Care Severity of Illness Scoring Systems in Patients With Coronavirus Disease 2019: A Retrospective Analysis of Three U.K. ICUs

From Critical Care Medicine

In this letter, the authors discuss APACHE II scores being used to predict mortality in coronavirus disease 2019 patients, however it may not be replicable.


Early Percutaneous Tracheostomy in Coronavirus Disease 2019: Association With Hospital Mortality and Factors Associated With Removal of Tracheostomy Tube at ICU Discharge. A Cohort Study on 121 Patients

From Critical Care Medicine

This study shows how early percutaneous tracheostomy was safe and effective in coronavirus disease 2019 patients, giving a good chance of survival and of weaning from tracheostomy cannula at ICU discharge.


Editorial: Coronavirus Disease 2019 Acute Respiratory Failure: Almitrine Drug Resuscitation or Resuscitating Patients by Almitrine?

From Critical Care Medicine

In this editorial, the author discusses the seeming benefits of using almitrine for severe hypoxia in patients with coronavirus disease 19 induced acute respiratory distress syndrome.


Editorial: Cardiopulmonary Resuscitation in Coronavirus Disease 2019: Rebalancing Risk, Reward, and Autonomy

From Critical Care Medicine

In this editorial, the authors discuss the risks of healthcare professionals performing cardiopulmonary resuscitation on coronavirus disease 2019 patients.


Editorial: Survival From Severe Coronavirus Disease 2019: Is It Changing?

From Critical Care Medicine

In this editorial, the authors discuss the factors behind why patients had a higher likelihood of surviving coronavirus disease 2019 in June 2020 compared to March 2020.


Prognostic Factors for 30-Day Mortality in Critically Ill Patients With Coronavirus Disease 2019: An Observational Cohort Study

From Critical Care Medicine

The authors identified patient characteristics that predict an increased likelihood of death within 30 days of the start of critical care for patients with coronavirus disease 2019, which included age, ethnicity, deprivation, body mass index, and prior dependency, among other characteristics.


Unexpectedly High Frequency of Enterococcal Bloodstream Infections in Coronavirus Disease 2019 Patients Admitted to an Italian ICU: An Observational Study

From Critical Care Medicine

The authors found that coronavirus disease 2019 seemed to increase the frequency of bloodstream infections (particularly Enterococcus-related bloodstream infection) after ICU admission.


Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor

From Critical Care Medicine

The authors found that procalcitonin exerts a moderate but harmful effect on disease progression in experimental septic shock, and suggests a potential therapeutic application for calcitonin gene-related peptide receptor inhibitors in sepsis.


De Novo Renal Failure and Clinical Outcomes of Patients With Critical Coronavirus Disease 2019

From Critical Care Medicine 

The authors found that respiratory failure conveys significant mortality risk in patients with coronavirus disease 2019 and survival with concomitant renal failure is rare.


Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

From Critical Care Medicine

The authors tested and found that a previously defined bacterial sepsis endotype classifier recapitulates the same clinical and immunological endotypes in viral sepsis (coronavirus disease 2019).


Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C

From Critical Care Medicine

The authors invesitated the safety and efficacy of megadose sodium ascorbate in sepsis.


Rapid Transition of a PICU Space and Staff to Adult Coronavirus Disease 2019 ICU Care

From Critical Care Medicine

The authors describe how a PICU and a PICU care team were incorporated into a hospital-wide ICU care model during the coronavirus disease 2019 pandemic.


Letter to the Editor: Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort St

From Critical Care Explorations

The authors conducted a multicenter cohort study to determine the effect of drug therapies on survival in mechanically ventilated patients with coronavirus disease 2019.


Delirium Incidence, Duration, and Severity in Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Explorations

The authors found that mechanical ventilation was significantly associated with odds of delirium even after adjustment for sedatives.


Brain Death Evaluation in Children With Suspected or Confirmed Coronavirus Disease 2019

From Pediatric Critical Care Medicine

The authors discuss the challenges of conducting a death by neurologic criteria or brain death evaluation in the coronavirus disease 2019 era and provide guidance to mitigate viral transmission risk and maintain patient safety during testing.


Feasibility and Safety of Prone Position Transport for Severe Hypoxemic Respiratory Failure Due to Coronavirus Disease 2019

From Critical Care Explorations

The authors found that critical care transport of severe hypoxemic respiratory failure patients with coronavirus disease 2019 in the prone position is safe when performed by a dedicated team of critical care nurse and paramedics with an established protocol.


Experience With Cardiology-Oriented Outcomes in Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Explorations

The authors share data and recommendations from a multidisciplinary team to highlight our institution’s clinical experiences and guidelines for managing cardiovascular complications of coronavirus disease 2019.


A Novel Low-Cost Ventilator for Use in a Worldwide Pandemic: The Portsmouth Ventilator

From Critical Care Explorations

In this study, the authors found that the Portsmouth Ventilator was able to perform well across all simulated pathologies and in vivo.


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