A paper published in the December 2011 issue of Toxicology and Applied Pharmacology, explores the dangers of particulate matter produced by wildfires.
Type: External Resource
- Coarse PM from wildfires is more cytotoxic to macrophages than “normal” coarse PM from ambient air at equivalent doses by mass.
- Exposure of cultured macrophages containing a reporter gene to wildfire coarse PM demonstrates activation of the NF–kB pathway.
- These studies demonstrate that oxidative stress is the major contributing mechanism to macrophage killing by wildfire coarse PM in vitro and in vivo.