Letter to the Editor: Bias Due to Cohort Construction in the Study of Timing of Invasive Ventilation

From Critical Care Explorations. In this Letter to the Editor, the authors respond to an article by Dupuis et al., congratulating the contribution to the problem of identifying which patients with hypoxemic respiratory failure truly benefit from invasive ventilation and suggesting future studies of invasive ventilation consider using the target trial concept in order to minimize bias and maximize the clinical applicability of results.

Yarnell CJ, Munshi L

Estimated Time: 4:31 min