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Content Type: Articles

Harmonizing Heterogeneous Endpoints in Coronavirus Disease 2019 Trials Without Loss of Information

From Critical Care Medicine The authors aim to provide hands-on statistical guidelines for harmonizing heterogeneous endpoints in coronavirus disease 2019 clinical trials.

   Estimated Time: 23:48 min Coronavirus, COVID-19, Statistics

Inflammatory Response and Phenotyping in Severe Acute Respiratory Infection From the Middle East Respiratory Syndrome Coronavirus and Other Etiologies

From Critical Care Medicine The authors evaluated the inflammatory response in patients with severe acute respiratory infection due to the Middle East respiratory syndrome and non-Middle East respiratory syndrome and assessed the presence of distinct inflammatory subpheno...

   Estimated Time: 23:33 Coronavirus, COVID-19

Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation

From Critical Care Explorations The authors present a case series of eleven patients, five treated with camostat mesylate and six treated with hydroxychloroquine.

   Estimated Time: 12:23 Case Presentations, Coronavirus, COVID-19, Therapies

A Propensity-Matched Cohort Study of Tocilizumab in Patients With Coronavirus Disease 2019

From Critical Care Explorations The authors assessed the impact of tocilizumab therapy and found that it was associated with significantly improved survival in coronavirus disease 2019 patients.

   Estimated Time: 23:31 Coronavirus, COVID-19, Therapies

Intravenous Immunoglobulin Plus Methylprednisolone Mitigate Respiratory Morbidity in Coronavirus Disease 2019

From Critical Care Explorations The authors piloted a randomized trial of IV immunoglobulin in coronavirus disease 2019 patients and found significantly improved hypoxia and reduced hospital length of stay.

   Estimated Time: 23:01 Clinical Trials, Coronavirus, COVID-19

Rescue Treatment With High-Dose Gaseous Nitric Oxide in Spontaneously Breathing Patients With Severe Coronavirus Disease 2019

From Critical Care Explorations The authors present a case series of patients who received nitric oxide inhalation as a rescue therapy for coronavirus disease 2019.

   Estimated Time: 13:51 Case Presentations, Coronavirus, COVID-19

Timing of Tracheostomy for Prolonged Respiratory Wean in Critically Ill Coronavirus Disease 2019 Patients: A Machine Learning Approach

From Critical Care Explorations The authors found that the optimal window for consideration of tracheostomy for ventilatory weaning in coronavirus disease 2019 patients is between day 13 and 17.

   Estimated Time: 24:55 Coronavirus, COVID-19

Frequency and Analysis of Unplanned Extubation in Coronavirus Disease 2019 Patients

From Critical Care Explorations The authors found that coronavirus disease 2019 patients have a higher incidence of unplanned extubation that requires reintubation than noncoronavirus disease 2019 patients.

   Estimated Time: 06:52 Coronavirus, COVID-19

Online Letter to the Editor: Analysis of Critical Care Severity of Illness Scoring Systems in Patients With Coronavirus Disease 2019: A Retrospective Analysis of Three U.K. ICUs

From Critical Care Medicine In this letter, the authors discuss APACHE II scores being used to predict mortality in coronavirus disease 2019 patients, however it may not be replicable.

   Estimated Time: 06:52 Coronavirus, COVID-19

Early Percutaneous Tracheostomy in Coronavirus Disease 2019: Association With Hospital Mortality and Factors Associated With Removal of Tracheostomy Tube at ICU Discharge. A Cohort Study on 121 Patients

From Critical Care Medicine This study shows how early percutaneous tracheostomy was safe and effective in coronavirus disease 2019 patients, giving a good chance of survival and of weaning from tracheostomy cannula at ICU discharge.

   Estimated Time: 21:30 Cardiovascular, Coronavirus, COVID-19

Editorial: Coronavirus Disease 2019 Acute Respiratory Failure: Almitrine Drug Resuscitation or Resuscitating Patients by Almitrine?

From Critical Care Medicine In this editorial, the author discusses the seeming benefits of using almitrine for severe hypoxia in patients with coronavirus disease 19 induced acute respiratory distress syndrome.

   Estimated Time: 07:02 ARDS, Cardiovascular, Coronavirus, COVID-19

Editorial: Cardiopulmonary Resuscitation in Coronavirus Disease 2019: Rebalancing Risk, Reward, and Autonomy

From Critical Care Medicine In this editorial, the authors discuss the risks of healthcare professionals performing cardiopulmonary resuscitation on coronavirus disease 2019 patients.

   Estimated Time: 14:15 Cardiovascular, Coronavirus, COVID-19, Resource Allocation

Editorial: Survival From Severe Coronavirus Disease 2019: Is It Changing?

From Critical Care Medicine In this editorial, the authors discuss the factors behind why patients had a higher likelihood of surviving coronavirus disease 2019 in June 2020 compared to March 2020.

   Estimated Time: 05:31 Coronavirus, COVID-19, Statistics

Prognostic Factors for 30-Day Mortality in Critically Ill Patients With Coronavirus Disease 2019: An Observational Cohort Study

From Critical Care Medicine The authors identified patient characteristics that predict an increased likelihood of death within 30 days of the start of critical care for patients with coronavirus disease 2019, which included age, ethnicity, deprivation, body mass index, an...

   Estimated Time: 24:43 Coronavirus, COVID-19, Statistics

Unexpectedly High Frequency of Enterococcal Bloodstream Infections in Coronavirus Disease 2019 Patients Admitted to an Italian ICU: An Observational Study

From Critical Care Medicine The authors found that coronavirus disease 2019 seemed to increase the frequency of bloodstream infections (particularly Enterococcus-related bloodstream infection) after ICU admission.

   Estimated Time: 24:15 Coinfections, Coronavirus, COVID-19

Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor

From Critical Care Medicine The authors found that procalcitonin exerts a moderate but harmful effect on disease progression in experimental septic shock, and suggests a potential therapeutic application for calcitonin gene-related peptide receptor inhibitors in sepsis.

   Estimated Time: 27:40 Coronavirus, COVID-19, Sepsis

De Novo Renal Failure and Clinical Outcomes of Patients With Critical Coronavirus Disease 2019

From Critical Care Medicine  The authors found that respiratory failure conveys significant mortality risk in patients with coronavirus disease 2019 and survival with concomitant renal failure is rare.

   Estimated Time: 20:37 AKI/Renal, Coronavirus, COVID-19

Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

From Critical Care Medicine The authors tested and found that a previously defined bacterial sepsis endotype classifier recapitulates the same clinical and immunological endotypes in viral sepsis (coronavirus disease 2019).

   Estimated Time: 19:48 Coronavirus, COVID-19, Sepsis

Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C

From Critical Care Medicine The authors invesitated the safety and efficacy of megadose sodium ascorbate in sepsis.

   Estimated Time: 26:19 Coronavirus, COVID-19, Sepsis, Therapies

Rapid Transition of a PICU Space and Staff to Adult Coronavirus Disease 2019 ICU Care

From Critical Care Medicine The authors describe how a PICU and a PICU care team were incorporated into a hospital-wide ICU care model during the coronavirus disease 2019 pandemic.

   Estimated Time: 17:03 Coronavirus, COVID-19, Resource Allocation