The National Heart, Lung and Blood Institute (NHLBI)
awarded a large 5-year R-24 research infrastructure
grant to Society member Dale Needham, FCPA, MD, PhD,
for a project entitled “Improving Long-Term Outcomes
Research for Acute Respiratory Failure.”
Dr. Needham is Director of the Outcomes After Critical
Illness and Surgery (OACIS) Group, a multidisciplinary
clinical and research group focused on understanding
and improving patient outcomes after critical illness and
surgery, at Johns Hopkins University School of Medicine.
This NIH-funded project has completed the
development of many resources for researchers
conducting long-term follow-up of patients surviving
acute respiratory failure and acute respiratory distress
syndrome (ARF/ARDS), including:
• Recommendations for long-term outcomes and
associated measurement instruments for research in
this patient population. A database of recommended
survey instruments and clinical testing methods for
evaluating the long-term physical, cognitive, and mental
health outcomes of survivors of ARF/ARDS is available
• Practical tools for maximizing patient cohort retention
for longitudinal long-term outcomes research studies.
Cohort retention tools are available at www.improvelto.
• Statistical tools and programs to appropriately
address the competing risk of mortality in analyzing
long-term functional outcomes in this patient
population. A software tool that imputes missing
data among survivors and then implements statistical
approaches for addressing mortality when evaluating
long-term functional outcomes is available at www.
Visit www.improvelto.com to learn more about this project and stay up to date on its progress.